| Gene Symbol |
Pmaip1
|
| Entrez Gene |
58801
|
| Alt Symbol |
Noxa
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phorbol-12-myristate-13-acetate-induced protein 1
|
| Other Description |
protein Noxa
|
| Swissprots |
Q9JM54
|
| Accessions |
EDL09665 Q9JM54 AB041230 BAA95781 AK043856 BAC31682 AK088556 BAC40421 AK143990 BAE25650 AK169914 BAE41454 BC050821 AAH50821 NM_021451 NP_067426
|
| Function |
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15901672, ECO:0000269|PubMed:16822983, ECO:0000269|PubMed:17389404}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:10807576}.
|
| Tissue Specificity |
Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney. {ECO:0000269|PubMed:16822983}.
|
| Top Pathways |
p53 signaling pathway, Viral carcinogenesis
|