Pmaip1

Gene Symbol Pmaip1
Entrez Gene 58801
Alt Symbol Noxa
Species Mouse
Gene Type protein-coding
Description phorbol-12-myristate-13-acetate-induced protein 1
Other Description protein Noxa
Swissprots Q9JM54
Accessions EDL09665 Q9JM54 AB041230 BAA95781 AK043856 BAC31682 AK088556 BAC40421 AK143990 BAE25650 AK169914 BAE41454 BC050821 AAH50821 NM_021451 NP_067426
Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15901672, ECO:0000269|PubMed:16822983, ECO:0000269|PubMed:17389404}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:10807576}.
Tissue Specificity Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney. {ECO:0000269|PubMed:16822983}.
Top Pathways p53 signaling pathway, Viral carcinogenesis

NOXA-BH3-Peptide-2 - SP2459b from Abgent, a WuXi AppTec company

Category Peptide
Prices $185.00
Sizes 1 mg

NOXA-BH3-Peptide-2 - SP2459a from Abgent, a WuXi AppTec company

Category Peptide
Prices $100.00
Sizes 500 µg

NOXA Control Peptide - AP30610CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

Noxa Peptide - 2437P from ProSci

Category Peptide
Species Human

Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1(Pmaip1) - CSB-YP018229MO CSB-EP018229MO CSB-BP018229MO CSB-MP018229MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), Recombinant Protein - MBS1370430 from MyBioSource

Category Protein
Prices $835.00, $835.00, $1,060.00, $1,060.00, $1,200.00, $1,200.00, $1,655.00, $1,655.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Recombinant Mouse PMAIP1 Protein - PMAIP1-13007M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse
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