Pmaip1

Gene Symbol Pmaip1
Entrez Gene 58801
Alt Symbol Noxa
Species Mouse
Gene Type protein-coding
Description phorbol-12-myristate-13-acetate-induced protein 1
Other Description protein Noxa
Swissprots Q9JM54
Accessions EDL09665 Q9JM54 AB041230 BAA95781 AK043856 BAC31682 AK088556 BAC40421 AK143990 BAE25650 AK169914 BAE41454 BC050821 AAH50821 NM_021451 NP_067426
Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. {ECO:0000250, ECO:0000269|PubMed:10807576, ECO:0000269|PubMed:15694340, ECO:0000269|PubMed:15901672, ECO:0000269|PubMed:16822983, ECO:0000269|PubMed:17389404}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:10807576}.
Tissue Specificity Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney. {ECO:0000269|PubMed:16822983}.
Top Pathways p53 signaling pathway, Viral carcinogenesis

NOXA CRISPR/Cas9 KO Plasmid (m) - sc-425521 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA HDR Plasmid (m) - sc-425521-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA Double Nickase Plasmid (m) - sc-425521-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA Double Nickase Plasmid (m2) - sc-425521-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA CRISPR Activation Plasmid (m) - sc-425521-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA CRISPR Activation Plasmid (m2) - sc-425521-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA Lentiviral Activation Particles (m) - sc-425521-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA Lentiviral Activation Particles (m2) - sc-425521-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

NOXA siRNA (m) - sc-37306 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

NOXA shRNA Plasmid (m) - sc-37306-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

NOXA shRNA (m) Lentiviral Particles - sc-37306-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU031541 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN38948 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38948 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PMAIP1 siRNA (Mouse) - CRM6132 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse PMAIP1 (NM_021451.2) - SHH378324 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Pmaip1(NM_021451.2) - SHR123664 from Creative biogene

Category siRNA
Species Reactivities Mouse

PMAIP1 shRNA Plasmid (Mouse) - CHM6132 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

PMAIP1 miRNA 3'UTR clone - MiUTR1M-09353 from Creative biogene

Species Reactivities Mouse
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