| Gene Symbol |
ACVR2A
|
| Entrez Gene |
92
|
| Alt Symbol |
ACTRII, ACVR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activin A receptor, type IIA
|
| Other Description |
activin receptor type-2A
|
| Swissprots |
P27037 D3DP85 Q6NWV2 Q92474 Q53TH4 B4DWQ2 B2RAB8
|
| Accessions |
AAX93050 CCF77014 EAX11561 EAX11562 P27037 AA125825 AK301629 BAG63114 AK314124 BAG36815 AW162986 BC067416 BC067417 AAH67417 BC067418 AAH67418 BC069707 AAH69707 BG616903 BM503220 BU676046 BX645435 D31770 BAA06548 DA531622 DN918410 M93415 AAA35504 T07746 W03601 X62381 CAA44245 X63128 CAA44839 XM_005263843 XP_005263900 NM_001278579 NP_001265508 NM_001278580 NP_001265509 NM_001616 NP_001607
|
| Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells
|
![Western Blot: Activin Receptor Type 2A Overexpression Lysate (Adult Normal) [NBP2-10986] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Activin Receptor Type 2A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9994_Activin%2520Receptor%2520Type%25202A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10986-img0001.jpg)