| Gene Symbol |
CCR1
|
| Entrez Gene |
1230
|
| Alt Symbol |
CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) receptor 1
|
| Other Description |
C-C CKR-1|C-C chemokine receptor type 1|CC-CKR-1|CCR-1|LD78 receptor|MIP-1alpha-R|RANTES receptor|RANTES-R|macrophage inflammatory protein 1-alpha receptor
|
| Swissprots |
P32246 Q86VA9
|
| Accessions |
EAW64756 EAW64757 P32246 AI089760 BC051306 AAH51306 BC064991 AAH64991 BT019908 AAV38711 BT019909 AAV38712 BX337412 CK903574 D10925 BAA01723 EU831462 ACE87149 EU831549 ACE86468 L09230 AAA58408 L10918 AAA36543 NM_001295 NP_001286
|
| Function |
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000269|PubMed:18587271}.
|
| Tissue Specificity |
Widely expressed in different hematopoietic cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|
![Western Blot: CCR1 Overexpression Lysate (Adult Normal) [NBL1-08887] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCR1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5997_CCR1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08887-img0002.jpg)