Gene Symbol | CCR1 |
---|---|
Entrez Gene | 1230 |
Alt Symbol | CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) receptor 1 |
Other Description | C-C CKR-1|C-C chemokine receptor type 1|CC-CKR-1|CCR-1|LD78 receptor|MIP-1alpha-R|RANTES receptor|RANTES-R|macrophage inflammatory protein 1-alpha receptor |
Swissprots | P32246 Q86VA9 |
Accessions | EAW64756 EAW64757 P32246 AI089760 BC051306 AAH51306 BC064991 AAH64991 BT019908 AAV38711 BT019909 AAV38712 BX337412 CK903574 D10925 BAA01723 EU831462 ACE87149 EU831549 ACE86468 L09230 AAA58408 L10918 AAA36543 NM_001295 NP_001286 |
Function | Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000269|PubMed:18587271}. |
Tissue Specificity | Widely expressed in different hematopoietic cells. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
CKR-1 CRISPR/Cas9 KO Plasmid (h) - sc-402247 from Santa Cruz Biotechnology
|
||||||||
CKR-1 HDR Plasmid (h) - sc-402247-HDR from Santa Cruz Biotechnology
|
||||||||
CKR-1 Double Nickase Plasmid (h) - sc-402247-NIC from Santa Cruz Biotechnology
|
||||||||
CKR-1 Double Nickase Plasmid (h2) - sc-402247-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CKR-1 CRISPR Activation Plasmid (h) - sc-402247-ACT from Santa Cruz Biotechnology
|
||||||||
CKR-1 CRISPR Activation Plasmid (h2) - sc-402247-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CKR-1 Lentiviral Activation Particles (h) - sc-402247-LAC from Santa Cruz Biotechnology
|
||||||||
CKR-1 Lentiviral Activation Particles (h2) - sc-402247-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CKR-1 siRNA (h) - sc-39880 from Santa Cruz Biotechnology
|
||||||||
CKR-1 shRNA Plasmid (h) - sc-39880-SH from Santa Cruz Biotechnology
|
||||||||
CKR-1 shRNA (h) Lentiviral Particles - sc-39880-V from Santa Cruz Biotechnology
|
||||||||
CCR1 RNAi - H00001230-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU156141 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1976 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1976 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR09504 from Sigma-Aldrich
|
||||||||
CCR1 siRNA (Human) - CRH0867 from Cohesion Biosciences
|
||||||||
CCR1 - MBS8221234 from MyBioSource
|
||||||||
shRNA set against Human CCR1 (NM_001295.2) - SHH258113 from Creative biogene
|
||||||||
shRNA set against Human CCR1(NM_001295.2) - SHG153079 from Creative biogene
|
||||||||
Human CCR1 siRNA - orb261369 from Biorbyt
|
||||||||
CCR1 shRNA Plasmid (Human) - CHH0867 from Cohesion Biosciences
|
||||||||
CCR1 miRNA 3'UTR clone - MiUTR1H-01824 from Creative biogene
|