OTX2

Gene Symbol OTX2
Entrez Gene 5015
Alt Symbol CPHD6, MCOPS5
Species Human
Gene Type protein-coding
Description orthodenticle homeobox 2
Other Description homeobox protein OTX2|orthodenticle homolog 2
Swissprots B2RAN5 Q9HAW3 P32243 Q9P2R1 Q6GTV3
Accessions AAG16243 AIZ97494 AIZ97495 BAA90425 EAW80692 EAW80693 P32243 AB593056 BAJ84003 AB593057 BAJ84004 AB593058 BAJ84005 AF093138 AAD31385 AK314271 BAG36932 BC032579 AAH32579 BE781530 BU176852 CV812961 DB294481 DQ890875 ABM81801 EU176492 ABW03293 NM_001270523 NP_001257452 NM_001270524 NP_001257453 NM_001270525 NP_001257454 NM_021728 NP_068374 NM_172337 NP_758840 NR_073034 NR_073036
Function Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Expressed in brain.

OTX2 (D7Y3J) Rabbit mAb - 11943 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7Y3J
Western blot analysis of extracts from Y79, D283 Med, and WERI-Rb-1 cells using OTX2 (D7Y3J) Rabbit mAb.

OTX2 Antibody - 8136 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

OTX2 (D-8) - sc-514195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OTX2 (D-8): sc-514195. Western blot analysis of OTX2 expression in NTERA-2 cl.D1 whole cell lysate.

OTX2 (T-13) - sc-30660 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OTX2 (P-15) - sc-30659 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OTX2 (P-15): sc-30659. Western blot analysis of OTX2 expression in T-47D whole cell lysate.

OTX2 (H-145) - sc-292478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OTX2 (H-145): sc-292478. Western blot analysis of OTX2 expression in HeLa nuclear extract (A) and mouse brain (B) and mouse cerebellum (C) tissue extracts.

OTX2 (Y-23) - sc-133873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
OTX2 (Y-23): sc-133873. Western blot analysis of OTX2 expression in Hep G2 nuclear extract.

Anti-Otx2 antibody - ab114138 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC-P image of Otx2 antibody (ab114138) on paraffin-embedded mouse embryo sections. The image on the left is of a WT embryo, whilst on the right is an embryo where Otx2 has been replaced with human Otx1 (hOtx1Otx2/Otx2). The sections underwent heat mediated antigen retrieval using Citrate Buffer, primary antibody was used at 1:500 dilution and Biocare Mach4 Kit was used to detect the primary antibody.

Anti-Otx2 antibody - ab76748 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Otx2 antibody (ab76748) at 1 µg/mlLane 1 : OTX1 Recombinant Protein at 0.1 µgLane 2 : OTX2 Overexpression Lysate at 20 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Otx2 antibody [1313CT817.185.162] - ab191232 from Abcam

Prices $376.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 1313CT817.185.162
Anti-Otx2 antibody [1313CT817.185.162] (ab191232) at 1/1000 dilution + Y79 cell line lysate at 35 µgSecondaryGoat anti-mouse IgG H&L (HRP) at 1/3000 dilution

Anti-Otx2 antibody [1H12C4B5] - ab130238 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H12C4B5
Overlay histogram showing Y79 cells stained with ab130238 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab130238, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in LoVo cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Otx2 antibody [EPR3348] - ab92326 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3348
Anti-Otx2 antibody [EPR3348] (ab92326) at 1/1000 dilution + Y79 cell lysate at 10 µgSecondaryHRP labelled goat anti-rabbit IgG at 1/1000 dilution

Anti-OTX2 Antibody (N-Terminus) - LS-C144921 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OTX2 Antibody (N-Terminus) - LS-C153466 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OTX2 Antibody (aa86-135) - LS-C29716 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-OTX2 Antibody (FITC) - LS-C318145 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OTX2 Antibody - LS-C318146 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OTX2 Antibody (Biotin) - LS-C318147 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OTX2 Antibody (HRP) - LS-C319028 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OTX2 Antibody (Internal, clone EPR3348) - LS-C105729 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3348
Western blot analysis on Y79 cell lysate using anti-OTX2 antibody (LS-C105729).

Anti-OTX2 Antibody - LS-C341629 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OTX2 Antibody (aa10-60) - LS-C148664 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of OTX2 in Y79 cell lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148664 at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-OTX2 Antibody (aa110-159) - LS-C79963 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-OTX2 Antibody (aa108-157) - LS-C109663 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OTX2 antibody LS-C109663 Western blot of Transfected 293T cell lysate.

Anti-OTX2 Antibody (Internal, clone EPR3347) - LS-C105730 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3347
IHC of paraffin-embedded human fetal brain tissue using anti-OTX2 antibody (LS-C105730).
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