| Gene Symbol |
PCGF2
|
| Entrez Gene |
7703
|
| Alt Symbol |
MEL-18, RNF110, ZNF144
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polycomb group ring finger 2
|
| Other Description |
DNA-binding protein Mel-18|polycomb group RING finger protein 2|ring finger protein 110|zinc finger protein 144
|
| Swissprots |
P35227 A6NGD8
|
| Accessions |
CAI84554 EAW60527 EAW60528 EAW60529 EAW60530 P35227 AM392769 CAL37647 AU123693 BC004858 AAH04858 BC024255 AAH24255 BX647429 CA421781 D13969 BAA03074 XM_005257640 XP_005257697 XM_005257641 XP_005257698 XM_005257642 XP_005257699 XM_006725342 XP_006725405 XM_006725344 XP_006725407 XM_006725345 XP_006725408 NM_007144 NP_009075
|
| Function |
Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similari
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21282530}.
|
| Tissue Specificity |
Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|
![Western Blot: MEL-18 Overexpression Lysate (Adult Normal) [NBL1-14174] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MEL-18.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2461_MEL-18%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14174-img0002.jpg)