PCGF2

Gene Symbol	PCGF2
Entrez Gene	7703
Alt Symbol	MEL-18, RNF110, ZNF144
Species	Human
Gene Type	protein-coding
Description	polycomb group ring finger 2
Other Description	DNA-binding protein Mel-18|polycomb group RING finger protein 2|ring finger protein 110|zinc finger protein 144
Swissprots	P35227 A6NGD8
Accessions	CAI84554 EAW60527 EAW60528 EAW60529 EAW60530 P35227 AM392769 CAL37647 AU123693 BC004858 AAH04858 BC024255 AAH24255 BX647429 CA421781 D13969 BAA03074 XM_005257640 XP_005257697 XM_005257641 XP_005257698 XM_005257642 XP_005257699 XM_006725342 XP_006725405 XM_006725344 XP_006725407 XM_006725345 XP_006725408 NM_007144 NP_009075
Function	Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similari
Subcellular Location	Nucleus {ECO:0000269|PubMed:21282530}.
Tissue Specificity	Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.
Top Pathways	Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Mel18 full length protein - ab131947 from Abcam Category Protein Source Wheat germ Species Human

Human Mel18 peptide - ab17569 from Abcam Category Peptide

Human Mel18 peptide - ab23085 from Abcam Category Peptide Species Human

Human Mel18 protein fragment - ab152813 from Abcam Category Protein Source Wheat germ Species Human

PCGF2 / MEL-18 Antibody Blocking Peptide - LS-E3707 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCGF2 / MEL-18 Antibody Blocking Peptide - LS-E25546 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MEL-18 Protein - H00007703-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MEL-18 Protein - H00007703-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PCGF2-Antibody-Center-Blocking-Peptide - BP14911c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEL18 blocking peptide - GTX25267-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Mel18 Peptide - AC21-0375-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF110 / PCGF2 - H00007703-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF110 / PCGF2 - H00007703-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF110 / PCGF2 - H00007703-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

RNF110 / PCGF2 - H00007703-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF110 / PCGF2 - H00007703-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MEL18 Peptide - 45-106P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

MEL18 fusion protein - ag2083 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Polycomb group RING finger protein 2(PCGF2) - CSB-YP017606HU CSB-EP017606HU CSB-BP017606HU CSB-MP017606HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Polycomb group RING finger protein 2 (PCGF2), Recombinant Protein - MBS949567 from MyBioSource Category Protein Prices $1,105.00, $1,105.00, $1,340.00, $1,340.00, $1,750.00, $1,750.00, $2,215.00, $2,215.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MEL18/PCGF2, Peptide - MBS426090 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

MEL-18 Recombinant Protein Antigen - NBP2-13739PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PCGF2 Peptide, Human - M34GP11439H from Creative Peptides Category Peptide Source Synthetic. Species Human

MEL-18 Recombinant Protein Antigen - NBP2-56458PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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