PCGF2
| Gene Symbol | PCGF2 |
|---|---|
| Entrez Gene | 7703 |
| Alt Symbol | MEL-18, RNF110, ZNF144 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polycomb group ring finger 2 |
| Other Description | DNA-binding protein Mel-18|polycomb group RING finger protein 2|ring finger protein 110|zinc finger protein 144 |
| Swissprots | P35227 A6NGD8 |
| Accessions | CAI84554 EAW60527 EAW60528 EAW60529 EAW60530 P35227 AM392769 CAL37647 AU123693 BC004858 AAH04858 BC024255 AAH24255 BX647429 CA421781 D13969 BAA03074 XM_005257640 XP_005257697 XM_005257641 XP_005257698 XM_005257642 XP_005257699 XM_006725342 XP_006725405 XM_006725344 XP_006725407 XM_006725345 XP_006725408 NM_007144 NP_009075 |
| Function | Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similari |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:21282530}. |
| Tissue Specificity | Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle. |
| Top Pathways | Signaling pathways regulating pluripotency of stem cells |
Mel-18 CRISPR/Cas9 KO Plasmid (h) - sc-401776 from Santa Cruz Biotechnology
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Mel-18 HDR Plasmid (h) - sc-401776-HDR from Santa Cruz Biotechnology
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Mel-18 Double Nickase Plasmid (h) - sc-401776-NIC from Santa Cruz Biotechnology
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Mel-18 Double Nickase Plasmid (h2) - sc-401776-NIC-2 from Santa Cruz Biotechnology
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Mel-18 CRISPR Activation Plasmid (h) - sc-401776-ACT from Santa Cruz Biotechnology
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Mel-18 CRISPR Activation Plasmid (h2) - sc-401776-ACT-2 from Santa Cruz Biotechnology
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Mel-18 Lentiviral Activation Particles (h) - sc-401776-LAC from Santa Cruz Biotechnology
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Mel-18 Lentiviral Activation Particles (h2) - sc-401776-LAC-2 from Santa Cruz Biotechnology
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Mel-18 siRNA (h) - sc-38191 from Santa Cruz Biotechnology
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Mel-18 shRNA Plasmid (h) - sc-38191-SH from Santa Cruz Biotechnology
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Mel-18 shRNA (h) Lentiviral Particles - sc-38191-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU076571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1552 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1552 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12595 from Sigma-Aldrich
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PCGF2 siRNA (Human) - CRH5221 from Cohesion Biosciences
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MEL-18 RNAi - H00007703-R01 from Novus Biologicals
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shRNA set against Human PCGF2 (NM_007144.2) - SHH371816 from Creative biogene
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shRNA set against Human PCGF2(NM_007144.2) - SHR096672 from Creative biogene
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Human PCGF2 siRNA - orb265723 from Biorbyt
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PCGF2 shRNA Plasmid (Human) - CHH5221 from Cohesion Biosciences
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PCGF2 miRNA 3'UTR clone - MiUTR1H-07660 from Creative biogene
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