PRKCI

Gene Symbol PRKCI
Entrez Gene 5584
Alt Symbol DXS1179E, PKCI, nPKC-iota
Species Human
Gene Type protein-coding
Description protein kinase C, iota
Other Description PRKC-lambda/iota|aPKC-lambda/iota|atypical protein kinase C-lambda/iota|protein kinase C iota type
Swissprots P41743 D3DNQ4 Q8WW06
Accessions EAW78513 EAW78514 EAW78515 P41743 AB451443 BAG70257 AI521422 AK315342 BAG37741 BC022016 AAH22016 BC042405 BM767350 BQ014217 CN412350 L18964 AAA60171 L33881 AAB17011 NM_002740 NP_002731
Function Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non- small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response
Subcellular Location Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A.
Tissue Specificity Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers. {ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:7607695, ECO:0000269|PubMed:8226978}.
Top Pathways Tight junction, Insulin signaling pathway, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway

HTScan® PKCι Kinase Assay Kit - 7598 from Cell Signaling Technology

Category Assay Kit
Figure 1. PKCiota kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 1.32 mM CaCl2, 1 mM EDTA, 1.25 mM EGTA, 0.25 µg/50 µl phosphatidylserine, 50 ng/50 µl 1.2 Dioleyl-glycerol, 1.2 mM DTT, ATP: variable , 2.5 µg/50 µl PEG20,000, Substrate: PKC(19-31) (RFARKGSLRQKNV), 0.5µg/50 µl and Recombinant PKCiota: 50 ng/50 µl.

Protein Kinase C Iota, PKCi, Mouse, ELISA Kit - E-EL-M0977 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Protein Kinase C Iota, PKCI, Rat, ELISA Kit - E-EL-R0812 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Human PKCi ELISA Kit - HP0113 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine PKCi ELISA Kit - AP0113 from NeoScientific

Category ELISA Kit
Prices $300.00
Sizes 100 µl

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS083457 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS090118 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS060702 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS049711 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS049458 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS050245 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS066899 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS082515 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS092509 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1 - MBS093032 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00
Sizes 48 strip wells, 96 strip wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS067985 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS065953 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS060838 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.25ng/ml-8ng/ml.

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS077233 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS050875 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS076738 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS061644 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS061907 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS068310 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Interacting With Protein Kinase C Alpha 1, ELISA Kit - MBS072159 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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