| Gene Symbol |
PRKCI
|
| Entrez Gene |
5584
|
| Alt Symbol |
DXS1179E, PKCI, nPKC-iota
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase C, iota
|
| Other Description |
PRKC-lambda/iota|aPKC-lambda/iota|atypical protein kinase C-lambda/iota|protein kinase C iota type
|
| Swissprots |
P41743 D3DNQ4 Q8WW06
|
| Accessions |
EAW78513 EAW78514 EAW78515 P41743 AB451443 BAG70257 AI521422 AK315342 BAG37741 BC022016 AAH22016 BC042405 BM767350 BQ014217 CN412350 L18964 AAA60171 L33881 AAB17011 NM_002740 NP_002731
|
| Function |
Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non- small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response
|
| Subcellular Location |
Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A.
|
| Tissue Specificity |
Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers. {ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:7607695, ECO:0000269|PubMed:8226978}.
|
| Top Pathways |
Tight junction, Insulin signaling pathway, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway
|