PRKCI

Gene Symbol	PRKCI
Entrez Gene	5584
Alt Symbol	DXS1179E, PKCI, nPKC-iota
Species	Human
Gene Type	protein-coding
Description	protein kinase C, iota
Other Description	PRKC-lambda/iota|aPKC-lambda/iota|atypical protein kinase C-lambda/iota|protein kinase C iota type
Swissprots	P41743 D3DNQ4 Q8WW06
Accessions	EAW78513 EAW78514 EAW78515 P41743 AB451443 BAG70257 AI521422 AK315342 BAG37741 BC022016 AAH22016 BC042405 BM767350 BQ014217 CN412350 L18964 AAA60171 L33881 AAB17011 NM_002740 NP_002731
Function	Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non- small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response
Subcellular Location	Cytoplasm. Membrane. Endosome. Nucleus. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A.
Tissue Specificity	Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers. {ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:7607695, ECO:0000269|PubMed:8226978}.
Top Pathways	Tight junction, Insulin signaling pathway, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC iota full length protein - ab60850 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PKC iota full length protein - ab159204 from Abcam Category Protein Source Wheat germ Species Human

Human PKC iota full length protein - ab42601 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PKC iota protein fragment - ab159205 from Abcam Category Protein Source Wheat germ Species Human

PRKCI / PKC Iota Antibody Blocking Peptide - LS-E20483 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCI / PKC Iota Antibody Blocking Peptide - LS-E8612 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKC iota Recombinant Protein - H00005584-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PKC iota Partial Recombinant Protein - H00005584-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PKC iota Protein - P4189 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

PKC iota Recombinant Protein - P4760 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

PKC iota Protein - NBP1-99882 from Novus Biologicals Category Protein Prices $309.00 Sizes 5 µg

PKC iota Peptide - P2109 from Novus Biologicals Category Peptide Species Human

PKC-iota-Antibody-N-term-Blocking-Peptide - BP7022a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PRKCI GST tag protein - orb83976 from Biorbyt Category Protein Prices $238.00, $323.00 Sizes 20 μg, 50 μg Source Insect Species Human

PRKCI Blocking Peptide - 33R-9357 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRKCI - H00005584-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCI - H00005584-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCI - H00005584-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCI - H00005584-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCI - P4189 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PRKCI - P4760 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PRKCI fusion protein - ag4990 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PKC iota/lambda, Active Human Recombinant Protein - GWB-2E2FCC from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

Recombinant Human Protein Kinase C, Iota, GST-tagged, Active - PRKCI-405H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human PRKCI, Fc tagged - PRKCI-757H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

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