EXOSC7

Gene Symbol	EXOSC7
Entrez Gene	23016
Alt Symbol	EAP1, RRP42, Rrp42p, hRrp42p, p8
Species	Human
Gene Type	protein-coding
Description	exosome component 7
Other Description	exosome complex component RRP42|exosome complex exonuclease RRP42|ribosomal RNA-processing protein 42
Swissprots	Q96E72 Q15024
Accessions	EAW64731 EAW64732 EAW64733 EAW64734 Q15024 AK090511 AK130053 AK295779 BAG58602 AK315741 BAG38096 BC012831 AAH12831 BU153856 D29958 BAA06226 XR_245104 XR_940394 NM_015004 NP_055819 NR_023353
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EXOSC7 (A-1) - sc-393686 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EXOSC7 (D-20) - sc-83407 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EXOSC7 (E-12) - sc-393685 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EXOSC7 (E-17) - sc-83408 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EXOSC7 (H-159) - sc-366172 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EXOSC7 (N-18) - sc-83410 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EXOSC7 (A-25) - sc-133570 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-EXOSC7 antibody - ab89104 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-EXOSC7 antibody [2335C2a] - ab50754 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2335C2a

Anti-EXOSC7 antibody [2E5] - ab119788 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2E5

Anti-EXOSC7 antibody [3B2] - ab119382 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B2

Anti-EXOSC7 antibody [EPR7451] - ab128938 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7451

Anti-EXOSC7 antibody [EPR7452] - ab126750 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7452

Anti-EXOSC7 Antibody - LS-C65797 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-EXOSC7 Antibody (aa71-120) - LS-C30706 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EXOSC7 Antibody (aa36-85) - LS-C110568 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EXOSC7 Antibody (aa192-292) - LS-C307944 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EXOSC7 Antibody - LS-C307946 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-EXOSC7 Antibody (Internal, clone EPR7451) - LS-C152437 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7451

Anti-EXOSC7 Antibody (clone 2335C2a) - LS-C184394 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2335C2a

Anti-EXOSC7 Antibody (Internal, clone EPR7452) - LS-C152361 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7452

Anti-EXOSC7 Antibody (clone 2F5) - LS-C173707 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2F5

Anti-EXOSC7 Antibody (clone 1F7) - LS-C337614 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1F7

Anti-EXOSC7 Antibody (clone 2E5) - LS-C173706 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2E5

Anti-EXOSC7 Antibody (clone 1E8) - LS-C337613 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E8

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