| Gene Symbol |
EXOSC7
|
| Entrez Gene |
23016
|
| Alt Symbol |
EAP1, RRP42, Rrp42p, hRrp42p, p8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exosome component 7
|
| Other Description |
exosome complex component RRP42|exosome complex exonuclease RRP42|ribosomal RNA-processing protein 42
|
| Swissprots |
Q96E72 Q15024
|
| Accessions |
EAW64731 EAW64732 EAW64733 EAW64734 Q15024 AK090511 AK130053 AK295779 BAG58602 AK315741 BAG38096 BC012831 AAH12831 BU153856 D29958 BAA06226 XR_245104 XR_940394 NM_015004 NP_055819 NR_023353
|
| Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
|
| Top Pathways |
RNA degradation
|