EXOSC7

Gene Symbol	EXOSC7
Entrez Gene	23016
Alt Symbol	EAP1, RRP42, Rrp42p, hRrp42p, p8
Species	Human
Gene Type	protein-coding
Description	exosome component 7
Other Description	exosome complex component RRP42|exosome complex exonuclease RRP42|ribosomal RNA-processing protein 42
Swissprots	Q96E72 Q15024
Accessions	EAW64731 EAW64732 EAW64733 EAW64734 Q15024 AK090511 AK130053 AK295779 BAG58602 AK315741 BAG38096 BC012831 AAH12831 BU153856 D29958 BAA06226 XR_245104 XR_940394 NM_015004 NP_055819 NR_023353
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC7 full length protein - ab161502 from Abcam Category Protein Source Wheat germ Species Human

Human EXOSC7 full length protein - ab180350 from Abcam Category Protein Source E. coli Species Human

Human EXOSC7 protein fragment - ab161503 from Abcam Category Protein Source Wheat germ Species Human

EXOSC7 Antibody Blocking Peptide - LS-E14952 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Exosome component 7 Recombinant Protein - H00023016-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Exosome component 7 Partial Recombinant Protein - H00023016-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EXOSC7-Antibody-C-term-Blocking-Peptide - BP2855b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC7-Antibody-N-term-Blocking-Peptide - BP2855a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXOSC7 Blocking Peptide - 33R-2780 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC7 Blocking Peptide - 33R-4910 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC7 protein (His tag) - 80R-3887 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

EXOSC7 (1-291, His-tag) - AR51574PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

EXOSC7 (1-291, His-tag) - AR51574PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

EXOSC7 - H00023016-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EXOSC7 - H00023016-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EXOSC7 - H00023016-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EXOSC7 - H00023016-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EXOSC7, 1-291aa, Human, His tag, E.coli - 01-P2754 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

EXOSC7 fusion protein - Ag18322 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EXOSC7 fusion protein - Ag18212 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EXOSC7, His-tagged - EXOSC7-12599H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EXOSC7, His-tagged - EXOSC7-261H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exosome complex component RRP42(EXOSC7) - CSB-YP614876HU CSB-EP614876HU CSB-BP614876HU CSB-MP614876HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXOSC7, 1-291aa, Human, His tag, E.coli - ATGP2754 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

EXOSC7 (transcript variant 1) - TP301419 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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