| Gene Symbol |
FANCM
|
| Entrez Gene |
57697
|
| Alt Symbol |
FAAP250, KIAA1596
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Fanconi anemia, complementation group M
|
| Other Description |
ATP-dependent RNA helicase FANCM|Fanconi anemia group M protein|fanconi anemia-associated polypeptide of 250 kDa|protein Hef ortholog
|
| Swissprots |
Q3YFH9 B2RTQ9 Q8IYD8 Q9HCH6 Q8N9X6
|
| Accessions |
EAW65781 EAW65782 EAW65783 EAW65784 Q8IYD8 AB046816 BAB13422 AK001672 AK093422 BAC04159 AL833656 BC036056 AAH36056 BC140776 AAI40777 BC144511 AAI44512 BC156490 AAI56491 BX500546 DQ140356 AAZ53290 JF432109 ADZ15326 XM_005267929 XP_005267986 XM_011537034 XP_011535336 XM_011537035 XP_011535337 XM_011537036 XP_011535338 XM_011537037 XP_011535339 NM_001308133 NP_001295062 NM_001308134 NP_001295063 NM_020937 NP_065988
|
| Function |
ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|Ref.8, ECO:0000269|Ref.9}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16116422, ECO:0000269|Ref.8, ECO:0000269|Ref.9}.
|
| Top Pathways |
Fanconi anemia pathway
|