TRRAP

Gene Symbol TRRAP
Entrez Gene 8295
Alt Symbol PAF350/400, PAF400, STAF40, TR-AP, Tra1
Species Human
Gene Type protein-coding
Description transformation/transcription domain-associated protein
Other Description 350/400 kDa PCAF-associated factor|tra1 homolog
Swissprots Q9Y6H4 A4D265 Q9Y4A5 O75218 Q9Y631
Accessions AAC27675 AAC62433 EAL23887 EAW76693 EAW76694 EAW76695 EAW76696 EAW76697 EAW76698 EAW76699 EAW76700 Q9Y4A5 AB209489 BAD92726 AF076974 AAD09420 AF110377 AAD04629 AL050077 BC032759 AAH32759 BQ006165 DA113420 NM_001244580 NP_001231509 NM_003496 NP_003487
Function Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1- like com
Subcellular Location Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9708738}.
Top Pathways HTLV-I infection

TRRAP (P2032) Antibody - 3967 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell lysates from Jurkat, NIH/3T3 and COS cells using TRRAP (P2032) Antibody.

TRRAP (D2966) Antibody - 3966 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using TRRAP (D2966) Antibody.

TRRAP (H-300) - sc-11411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ChIP analysis of coactivator recruitment on Cyclin D2 promoter in C2C12 cells treated with LiCl and serum. Antibodies tested include β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496, β-catenin (E-5): sc-7963, Tip60 (N-17): sc-5725, TRRAP (T-17): sc-5405, TRRAP (Y-18): sc-12375, TRRAP (F-20): sc-12376, TRRAP (H-300): sc-11411, CBP (A-22): sc-369, CBP (C-20): sc-583, CBP (451): sc-1211, CPB (C-1): sc-7300, p300 (H-272): sc-8981, p300 (N-15): sc-584 and p300 (C-20): sc-585. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Kioussi <i>et al</i>., Cell 2002, 111: 673-685.

TRRAP (T-17) - sc-5405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRRAP (T-17): sc-5405. Western blot analysis of TRRAP expression in HeLa (A), K-562 (B) and Jurkat (C) nuclear extracts.

Anti-TRRAP antibody - ab72509 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation/ Western Blot of TRRAP. Lane 1: ab72509 at 3µg/mg whole cell lysate. Lane 2: Control IgG. Another antibody to TRRAP was used at 1µg/ml for WB. Whole cell lysate from Hela cells at 1mg for IP, 20% of IP loaded. Chemiluminescence with an exposure time of 30 seconds.

Anti-TRRAP antibody [EPR14952] - ab183517 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14952
All lanes : Anti-TRRAP antibody [EPR14952] (ab183517) at 1/20000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : MOLT4 cell lysateLane 4 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TRRAP antibody [EPR14952-81] - ab187166 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14952-81
All lanes : Anti-TRRAP antibody [EPR14952-81] (ab187166) at 1/2000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : Molt-4 cell lysateLane 4 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-TRRAP antibody - ChIP Grade - ab73546 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRRAP antibody - ChIP Grade (ab73546) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Nuclear Lysate (ab14844)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Tra1 / TRRAP Antibody (aa2824-2950) - LS-C42837 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody - LS-C76603 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (aa3275-3325) - LS-C89813 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (C-Terminus) - LS-C89812 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (aa3273-3460) - LS-C42838 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody - LS-C76604 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (aa3809-3859) - LS-C89814 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (aa2824-2950) - LS-C10883 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (aa3273-3460) - LS-C10884 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (C-Terminus, FITC) - LS-C206951 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (C-Terminus, PE) - LS-C206953 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (C-Terminus, AP) - LS-C206948 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (C-Terminus, Biotin) - LS-C206950 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (C-Terminus, APC) - LS-C206949 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (Internal, Biotin) - LS-C206956 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (Internal, FITC) - LS-C206957 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Tra1 / TRRAP Antibody (C-Terminus, Azide-free, HRP) - LS-C209168 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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