TRRAP
| Gene Symbol | TRRAP |
|---|---|
| Entrez Gene | 8295 |
| Alt Symbol | PAF350/400, PAF400, STAF40, TR-AP, Tra1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transformation/transcription domain-associated protein |
| Other Description | 350/400 kDa PCAF-associated factor|tra1 homolog |
| Swissprots | Q9Y6H4 A4D265 Q9Y4A5 O75218 Q9Y631 |
| Accessions | AAC27675 AAC62433 EAL23887 EAW76693 EAW76694 EAW76695 EAW76696 EAW76697 EAW76698 EAW76699 EAW76700 Q9Y4A5 AB209489 BAD92726 AF076974 AAD09420 AF110377 AAD04629 AL050077 BC032759 AAH32759 BQ006165 DA113420 NM_001244580 NP_001231509 NM_003496 NP_003487 |
| Function | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1- like com |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9708738}. |
| Top Pathways | HTLV-I infection |
TRRAP CRISPR/Cas9 KO Plasmid (h) - sc-402748 from Santa Cruz Biotechnology
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TRRAP HDR Plasmid (h) - sc-402748-HDR from Santa Cruz Biotechnology
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TRRAP Double Nickase Plasmid (h) - sc-402748-NIC from Santa Cruz Biotechnology
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TRRAP Double Nickase Plasmid (h2) - sc-402748-NIC-2 from Santa Cruz Biotechnology
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TRRAP CRISPR Activation Plasmid (h) - sc-402748-ACT from Santa Cruz Biotechnology
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TRRAP CRISPR Activation Plasmid (h2) - sc-402748-ACT-2 from Santa Cruz Biotechnology
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TRRAP Lentiviral Activation Particles (h) - sc-402748-LAC from Santa Cruz Biotechnology
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TRRAP Lentiviral Activation Particles (h2) - sc-402748-LAC-2 from Santa Cruz Biotechnology
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TRRAP siRNA (h) - sc-36746 from Santa Cruz Biotechnology
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TRRAP shRNA Plasmid (h) - sc-36746-SH from Santa Cruz Biotechnology
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TRRAP shRNA (h) Lentiviral Particles - sc-36746-V from Santa Cruz Biotechnology
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TRRAP RNAi - H00008295-R01 from Novus Biologicals
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MISSION® siRNA - SIHK2354 from Sigma-Aldrich
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MISSION® siRNA - SIHK2355 from Sigma-Aldrich
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MISSION® siRNA - SIHK2356 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22068 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22068 from Sigma-Aldrich
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TRRAP siRNA (Human) - CRH5430 from Cohesion Biosciences
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TRRAP - MBS8226521 from MyBioSource
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shRNA set against Human Trrap (NM_003496.3) - SHH435816 from Creative biogene
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Human TRRAP siRNA - orb265932 from Biorbyt
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TRRAP shRNA Plasmid (Human) - CHH5430 from Cohesion Biosciences
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TRRAP miRNA 3'UTR clone - MiUTR3H-05557 from Creative biogene
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