TRRAP

Gene Symbol	TRRAP
Entrez Gene	8295
Alt Symbol	PAF350/400, PAF400, STAF40, TR-AP, Tra1
Species	Human
Gene Type	protein-coding
Description	transformation/transcription domain-associated protein
Other Description	350/400 kDa PCAF-associated factor|tra1 homolog
Swissprots	Q9Y6H4 A4D265 Q9Y4A5 O75218 Q9Y631
Accessions	AAC27675 AAC62433 EAL23887 EAW76693 EAW76694 EAW76695 EAW76696 EAW76697 EAW76698 EAW76699 EAW76700 Q9Y4A5 AB209489 BAD92726 AF076974 AAD09420 AF110377 AAD04629 AL050077 BC032759 AAH32759 BQ006165 DA113420 NM_001244580 NP_001231509 NM_003496 NP_003487
Function	Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1- like com
Subcellular Location	Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9708738}.
Top Pathways	HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRRAP peptide - ab101312 from Abcam Category Peptide

Human TRRAP protein fragment - ab159983 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human TRRAP Protein - H00008295-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRRAP / PAF400 - H00008295-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRRAP / PAF400 - H00008295-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Transformation/Transcription Domain Associated Protein (TRRAP) - RPG996Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Transformation/Transcription Domain Associated Protein (TRRAP) - RPG996Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Transformation/transcription domain-associated protein(TRRAP) - CSB-YP025100HU CSB-EP025100HU CSB-BP025100HU CSB-MP025100HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRRAP Protein - NBP1-87350PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

TRRAP-Antibody-Center-Blocking-Peptide - BP8056c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRRAP-Antibody-C-term-Blocking-Peptide - BP8056b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRRAP-Blocking-Peptide-C-term - BP21568b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRRAP Peptide, Human - M34GP16695H from Creative Peptides Category Peptide Source Synthetic. Species Human

TRRAP Recombinant Protein (OPCD07726) - OPCD07726 from Aviva Systems Biology Category Protein Source E.coli Species Human

TRRAP Recombinant Protein Antigen - NBP2-58076PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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