| Gene Symbol |
TRRAP
|
| Entrez Gene |
8295
|
| Alt Symbol |
PAF350/400, PAF400, STAF40, TR-AP, Tra1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transformation/transcription domain-associated protein
|
| Other Description |
350/400 kDa PCAF-associated factor|tra1 homolog
|
| Swissprots |
Q9Y6H4 A4D265 Q9Y4A5 O75218 Q9Y631
|
| Accessions |
AAC27675 AAC62433 EAL23887 EAW76693 EAW76694 EAW76695 EAW76696 EAW76697 EAW76698 EAW76699 EAW76700 Q9Y4A5 AB209489 BAD92726 AF076974 AAD09420 AF110377 AAD04629 AL050077 BC032759 AAH32759 BQ006165 DA113420 NM_001244580 NP_001231509 NM_003496 NP_003487
|
| Function |
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1- like com
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9708738}.
|
| Top Pathways |
HTLV-I infection
|