SLC22A8

Gene Symbol	SLC22A8
Entrez Gene	9376
Alt Symbol	OAT3
Species	Human
Gene Type	protein-coding
Description	solute carrier family 22 (organic anion transporter), member 8
Other Description	hOAT3|organic anion transporter 3|solute carrier family 22 member 8
Swissprots	F5GWA8 B4DPH7 Q8TCC7 F5H5J1 Q59EW9 O95820 Q96TC1
Accessions	EAW74133 EAW74134 EAW74135 Q8TCC7 AB042505 BAB47393 AB209692 BAD92929 AF097491 AAD19357 AK123243 AK298341 BAG60589 AK298351 BAG60596 AK307850 AK313187 BAG36004 BC022387 AAH22387 BP276255 DA628705 DA633836 DQ892017 ABM82943 DQ895207 ABM86133 XM_011545364 XP_011543666 NM_001184732 NP_001171661 NM_001184733 NP_001171662 NM_001184736 NP_001171665 NM_004254 NP_004245
Function	Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). {ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:16455804}.
Subcellular Location	Basolateral cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in kidney. {ECO:0000269|PubMed:11912245}.
Top Pathways	Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SLC22A8 293T Cell Transient Overexpression Lysate(Denatured) - H00009376-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SLC22A8 overexpression lysate - LY401365 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SLC22A8 293 Cell Lysate - 401246 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SLC22A8 Overexpression Lysate (Native) - NBL1-16042 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SLC22A8 Over-expression Lysate Product - GWB-2917A3 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SLC22A8 Overexpression Lysate (Denatured) - H00009376-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

SLC22A8 Overexpression Lysate (Denatured) - H00009376-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human SLC22A8 Knockdown Stable Cell Line - CSC-DC014395 from Creative biogene Category Cell Line Species Human

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