SLC22A8

Gene Symbol SLC22A8
Entrez Gene 9376
Alt Symbol OAT3
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic anion transporter), member 8
Other Description hOAT3|organic anion transporter 3|solute carrier family 22 member 8
Swissprots F5GWA8 B4DPH7 Q8TCC7 F5H5J1 Q59EW9 O95820 Q96TC1
Accessions EAW74133 EAW74134 EAW74135 Q8TCC7 AB042505 BAB47393 AB209692 BAD92929 AF097491 AAD19357 AK123243 AK298341 BAG60589 AK298351 BAG60596 AK307850 AK313187 BAG36004 BC022387 AAH22387 BP276255 DA628705 DA633836 DQ892017 ABM82943 DQ895207 ABM86133 XM_011545364 XP_011543666 NM_001184732 NP_001171661 NM_001184733 NP_001171662 NM_001184736 NP_001171665 NM_004254 NP_004245
Function Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). {ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:16455804}.
Subcellular Location Basolateral cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in kidney. {ECO:0000269|PubMed:11912245}.
Top Pathways Bile secretion

OAT3 (C-12) - sc-107833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OAT3 (H-44) - sc-98807 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OAT3 (H-44): sc-98807. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic and membrane staining of Purkinje cells and cytoplasmic staining of cells in molecular layer.

OAT3 (P-13) - sc-107836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SLC22A8 antibody - ab104688 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-SLC22A8 antibody - ab69883 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SLC22A8 antibody (ab69883) at 1/500 dilutionLane 1 : SLC22A8 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-SLC22A8 antibody - ab83789 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC22A8 antibody (ab83789) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal heart lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SLC22A8 / OAT3 Antibody (N-Terminus) - LS-C17010 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC22A8 / OAT3 Antibody (N-Terminus) - LS-C17011 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A8 / OAT3 Antibody (C-Terminus) - LS-C101919 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC22A8 antibody LS-C101919 Western blot of Fetal Heart lysate.

Anti-SLC22A8 / OAT3 Antibody - LS-C335295 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human breast cancer tissue using SLC22A8 antibody.

SLC22A8 Antibody - NBP1-92396 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: SLC22A8 Antibody [NBP1-92396] - Staining of human kidney shows moderate cytoplasmic positivity in renal tubules.

SLC22A8 Antibody - NBP1-60107 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SLC22A8 Antibody [NBP1-60107] - Human Heart lysate, concentration 0.2-1 ug/ml.

SLC22A8 Antibody - H00009376-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SLC22A8 Antibody [H00009376-B01P] - Analysis of SLC22A8 expression in rat kidney.

SLC22A8 Antibody (3C11) - H00009376-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C11
Western Blot: SLC22A8 Antibody (3C11) [H00009376-M02] - SLC22A8 monoclonal antibody (M02), clone 3C11. Analysis of SLC22A8 expression in rat muscle.

OAT-3 Polyclonal Antibody - bs-0609R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti OAT-3 Polyclonal Antibody, Unconjugated (bs-0609R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

OAT-3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-0609R-A350 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-0609R-A488 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-0609R-A555 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-0609R-A647 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, Cy3 Conjugated - bs-0609R-Cy3 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, Cy5 Conjugated - bs-0609R-Cy5 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, Cy5.5 Conjugated - bs-0609R-Cy5.5 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, Cy7 Conjugated - bs-0609R-Cy7 from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, FITC Conjugated - bs-0609R-FITC from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OAT-3 Polyclonal Antibody, Biotin Conjugated - bs-0609R-Biotin from Bioss

Prices $359.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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