SLC22A8

Gene Symbol	SLC22A8
Entrez Gene	9376
Alt Symbol	OAT3
Species	Human
Gene Type	protein-coding
Description	solute carrier family 22 (organic anion transporter), member 8
Other Description	hOAT3|organic anion transporter 3|solute carrier family 22 member 8
Swissprots	F5GWA8 B4DPH7 Q8TCC7 F5H5J1 Q59EW9 O95820 Q96TC1
Accessions	EAW74133 EAW74134 EAW74135 Q8TCC7 AB042505 BAB47393 AB209692 BAD92929 AF097491 AAD19357 AK123243 AK298341 BAG60589 AK298351 BAG60596 AK307850 AK313187 BAG36004 BC022387 AAH22387 BP276255 DA628705 DA633836 DQ892017 ABM82943 DQ895207 ABM86133 XM_011545364 XP_011543666 NM_001184732 NP_001171661 NM_001184733 NP_001171662 NM_001184736 NP_001171665 NM_004254 NP_004245
Function	Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). {ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:16455804}.
Subcellular Location	Basolateral cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in kidney. {ECO:0000269|PubMed:11912245}.
Top Pathways	Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC22A8 full length protein - ab160461 from Abcam Category Protein Source Wheat germ Species Human

Human SLC22A8 protein fragment - ab160462 from Abcam Category Protein Source Wheat germ Species Human

SLC22A8 / OAT3 Antibody Blocking Peptide - LS-E15292 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SLC22A8 Protein - H00009376-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SLC22A8 Protein - H00009376-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SLC22A8-Antibody-C-term-Blocking-peptide - BP12434b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

OAT3 peptide - orb73065 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

SLC22A8 Blocking Peptide - 33R-7064 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SLC22A8 / OAT3 - H00009376-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SLC22A8 / OAT3 - H00009376-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SLC22A8 / OAT3 - H00009376-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SLC22A8 fusion protein - Ag9795 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SLC22A8 fusion protein - ag9527 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SLC22A8, His-tagged - SLC22A8-2712H from Creative Biomart Category Protein Source E.coli Species Human

SLC22A8 Recombinant Protein Antigen - NBP1-92396PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SLC22A8 Peptide, Human - M34GP14395H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLC22A8 peptide - orb12937 from Biorbyt Category Peptide Prices $170.00 Sizes 1 mg

Solute carrier family 22 member 8 (SLC22A8), Recombinant Protein - MBS7097249 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Solute carrier family 22 member 8 (SLC22A8), Recombinant Protein - MBS7086824 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

Recombinant Human SLC22A8 Protein, GST-tagged - SLC22A8-3828H from Creative Biomart Category Protein Source Wheat Germ Species Human

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