SLC22A8

Gene Symbol SLC22A8
Entrez Gene 9376
Alt Symbol OAT3
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic anion transporter), member 8
Other Description hOAT3|organic anion transporter 3|solute carrier family 22 member 8
Swissprots F5GWA8 B4DPH7 Q8TCC7 F5H5J1 Q59EW9 O95820 Q96TC1
Accessions EAW74133 EAW74134 EAW74135 Q8TCC7 AB042505 BAB47393 AB209692 BAD92929 AF097491 AAD19357 AK123243 AK298341 BAG60589 AK298351 BAG60596 AK307850 AK313187 BAG36004 BC022387 AAH22387 BP276255 DA628705 DA633836 DQ892017 ABM82943 DQ895207 ABM86133 XM_011545364 XP_011543666 NM_001184732 NP_001171661 NM_001184733 NP_001171662 NM_001184736 NP_001171665 NM_004254 NP_004245
Function Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). {ECO:0000269|PubMed:14586168, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:15846473, ECO:0000269|PubMed:16455804}.
Subcellular Location Basolateral cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in kidney. {ECO:0000269|PubMed:11912245}.
Top Pathways Bile secretion

OAT3 CRISPR/Cas9 KO Plasmid (h) - sc-417153 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 HDR Plasmid (h) - sc-417153-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 Double Nickase Plasmid (h) - sc-417153-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 Double Nickase Plasmid (h2) - sc-417153-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 CRISPR Activation Plasmid (h) - sc-417153-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 CRISPR Activation Plasmid (h2) - sc-417153-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 Lentiviral Activation Particles (h) - sc-417153-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 Lentiviral Activation Particles (h2) - sc-417153-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT3 siRNA (h) - sc-96554 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OAT3 shRNA Plasmid (h) - sc-96554-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OAT3 shRNA (h) Lentiviral Particles - sc-96554-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC22A8 RNAi - H00009376-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU073371 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

SLC22A8 siRNA (Human) - CRH6212 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A8 - MBS8237668 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC22A8 (NM_004254.3) - SHH409252 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC22A8 siRNA - orb266714 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A8 shRNA Plasmid (Human) - CHH6212 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC22A8 miRNA 3'UTR clone - MiUTR4H-TG08184 from Creative biogene

Species Reactivities Human
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