| Gene Symbol |
NPEPPS
|
| Entrez Gene |
9520
|
| Alt Symbol |
AAP-S, MP100, PSA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aminopeptidase puromycin sensitive
|
| Other Description |
cytosol alanyl aminopeptidase|metalloproteinase MP100|puromycin-sensitive aminopeptidase
|
| Swissprots |
Q9NP16 P55786 Q6P145 B7Z463 Q9UEM2
|
| Accessions |
AAF70086 EAW94811 EAW94812 EAW94813 P55786 AA864462 AJ132583 CAA10709 AK095877 BAG53154 AK096491 AK096709 BAG53355 AK293450 BAH11510 AK293995 BAH11645 AK296887 BAH12449 AK297107 BAH12498 AK303037 BAH13885 AK311414 BC065294 AAH65294 BM723238 DB476543 XM_011525496 XP_011523798 NM_006310 NP_006301
|
| Function |
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:10978616}. Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level). {ECO:0000269|PubMed:10978616}.
|