| Gene Symbol |
DOK4
|
| Entrez Gene |
55715
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
docking protein 4
|
| Other Description |
IRS-5|IRS5|downstream of tyrosine kinase 4|insulin receptor substrate 5
|
| Swissprots |
Q9BTP2 Q9NVV3 O75209 Q8TEW6
|
| Accessions |
AAC24310 EAW82932 EAW82933 EAW82934 Q8TEW6 AF466369 AAL74195 AK001350 BAA91642 AK307270 AK315426 BAG37814 AW163719 BC001540 AAH01540 BC003541 AAH03541 DQ893008 ABM83934 DQ896254 ABM87253 XM_005256042 XP_005256099 XM_005256043 XP_005256100 XM_011523226 XP_011521528 NM_018110 NP_060580
|
| Function |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}.
|