| Gene Symbol |
CHGA
|
| Entrez Gene |
1113
|
| Alt Symbol |
CGA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromogranin A
|
| Other Description |
SP-I|betagranin (N-terminal fragment of chromogranin A)|catestatin|chromofungin|chromogranin-A|parathyroid secretory protein 1|pituitary secretory protein I
|
| Swissprots |
B2R9E9 Q9BQB5 Q6NR84 Q96E84 Q53FA8 Q96GL7 P10645
|
| Accessions |
AAB53685 EAW81505 EAW81506 P10645 AK223381 BAD97101 AK313757 BAG36496 BC001059 AAH01059 BC006459 AAH06459 BC009384 AAH09384 BC012755 AAH12755 BT006869 AAP35515 BX248263 CAD62591 DA201149 DQ891820 ABM82746 DQ895007 ABM85933 J03483 AAA52017 J03915 AAA52018 XM_011536370 XP_011534672 XM_011546640 XP_011544942 NM_001275 NP_001266 NM_001301690 NP_001288619
|
| Function |
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. {ECO:0000250}.
|
| Tissue Specificity |
GE-25 is found in the brain. {ECO:0000269|PubMed:7535395}.
|