| Gene Symbol |
RAB22A
|
| Entrez Gene |
57403
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB22A, member RAS oncogene family
|
| Other Description |
GTP-binding protein RAB22A|rab-22|ras-related protein Rab-22A
|
| Swissprots |
E1P605 B3KR86 Q8TF12 Q9H4E6 Q9UL26
|
| Accessions |
EAW75496 EAW75497 Q9UL26 AF091034 AAF00047 AJ276210 CAC10538 AK054767 AK091180 BAG52298 BC007036 AAH07036 BC015710 AAH15710 BC016864 BC042545 BC063457 AAH63457 BI457862 BT007046 AAP35695 DB452461 NM_020673 NP_065724
|
| Function |
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form. {ECO:0000269|PubMed:16537905, ECO:0000269|PubMed:21849477}.
|
| Subcellular Location |
Endosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Early endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
|
| Top Pathways |
Endocytosis
|
![Western Blot: RAB22A Overexpression Lysate (Adult Normal) [NBL1-15048] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAB22A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6542_RAB22A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15048-img0002.jpg)