Gene Symbol | RAB22A |
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Entrez Gene | 57403 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | RAB22A, member RAS oncogene family |
Other Description | GTP-binding protein RAB22A|rab-22|ras-related protein Rab-22A |
Swissprots | E1P605 B3KR86 Q8TF12 Q9H4E6 Q9UL26 |
Accessions | EAW75496 EAW75497 Q9UL26 AF091034 AAF00047 AJ276210 CAC10538 AK054767 AK091180 BAG52298 BC007036 AAH07036 BC015710 AAH15710 BC016864 BC042545 BC063457 AAH63457 BI457862 BT007046 AAP35695 DB452461 NM_020673 NP_065724 |
Function | Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form. {ECO:0000269|PubMed:16537905, ECO:0000269|PubMed:21849477}. |
Subcellular Location | Endosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Early endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. |
Top Pathways | Endocytosis |
Rab 22A CRISPR/Cas9 KO Plasmid (h) - sc-407820 from Santa Cruz Biotechnology
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Rab 22A HDR Plasmid (h) - sc-407820-HDR from Santa Cruz Biotechnology
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Rab 22A Double Nickase Plasmid (h) - sc-407820-NIC from Santa Cruz Biotechnology
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Rab 22A Double Nickase Plasmid (h2) - sc-407820-NIC-2 from Santa Cruz Biotechnology
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Rab 22A CRISPR Activation Plasmid (h) - sc-407820-ACT from Santa Cruz Biotechnology
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Rab 22A CRISPR Activation Plasmid (h2) - sc-407820-ACT-2 from Santa Cruz Biotechnology
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Rab 22A Lentiviral Activation Particles (h) - sc-407820-LAC from Santa Cruz Biotechnology
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Rab 22A Lentiviral Activation Particles (h2) - sc-407820-LAC-2 from Santa Cruz Biotechnology
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Rab 22A siRNA (h) - sc-76324 from Santa Cruz Biotechnology
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Rab 22A shRNA Plasmid (h) - sc-76324-SH from Santa Cruz Biotechnology
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Rab 22A shRNA (h) Lentiviral Particles - sc-76324-V from Santa Cruz Biotechnology
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RAB22A RNAi - H00057403-R01 from Novus Biologicals
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MISSION® esiRNA - EHU031651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17820 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17820 from Sigma-Aldrich
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RAB22A siRNA (Human) - CRJ1430 from Cohesion Biosciences
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RAB22A - MBS8231730 from MyBioSource
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shRNA set against Human RAB22A (NM_020673.2) - SHH388040 from Creative biogene
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shRNA set against Human RAB22A(NM_020673.2) - SHR158406 from Creative biogene
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Human RAB22A siRNA - orb271931 from Biorbyt
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RAB22A shRNA Plasmid (Human) - CHJ1430 from Cohesion Biosciences
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RAB22A miRNA 3'UTR clone - MiUTR1H-08547 from Creative biogene
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