Gene Symbol |
LY96
|
Entrez Gene |
23643
|
Alt Symbol |
ESOP-1, MD-2, MD2, ly-96
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
lymphocyte antigen 96
|
Other Description |
myeloid differentiation protein-2|protein MD-2
|
Swissprots |
B3Y6A5 E5RJJ7 Q9Y6Y9
|
Accessions |
CBX47650 EAW87024 Q9Y6Y9 AB018549 BAA78717 AB446498 BAG55275 AF168121 AAF89635 BC020690 AAH20690 BG435728 XM_011517508 XP_011515810 NM_001195797 NP_001182726 NM_015364 NP_056179
|
Function |
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
|
Subcellular Location |
Secreted, extracellular space.
|
Top Pathways |
Toll-like receptor signaling pathway, Pathogenic Escherichia coli infection, Toxoplasmosis, Pertussis
|