Gene Symbol | LY96 |
---|---|
Entrez Gene | 23643 |
Alt Symbol | ESOP-1, MD-2, MD2, ly-96 |
Species | Human |
Gene Type | protein-coding |
Description | lymphocyte antigen 96 |
Other Description | myeloid differentiation protein-2|protein MD-2 |
Swissprots | B3Y6A5 E5RJJ7 Q9Y6Y9 |
Accessions | CBX47650 EAW87024 Q9Y6Y9 AB018549 BAA78717 AB446498 BAG55275 AF168121 AAF89635 BC020690 AAH20690 BG435728 XM_011517508 XP_011515810 NM_001195797 NP_001182726 NM_015364 NP_056179 |
Function | Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS. |
Subcellular Location | Secreted, extracellular space. |
Top Pathways | Toll-like receptor signaling pathway, Pathogenic Escherichia coli infection, Toxoplasmosis, Pertussis |