Gene Symbol | MYLK3 |
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Entrez Gene | 91807 |
Alt Symbol | MLCK, MLCK2, caMLCK |
Species | Human |
Gene Type | protein-coding |
Description | myosin light chain kinase 3 |
Other Description | MLC kinase|cardiac-MLCK|cardiac-MyBP-C associated Ca/CaM kinase|cardiac-MyBP-C-associated Ca/CaM kinase|putative myosin light chain kinase 3 |
Swissprots | Q96DV1 B7Z5U8 Q32MK0 Q32MK1 B5BUL9 |
Accessions | CCQ43924 EAW82687 Q32MK0 AB451455 BAG70269 AJ247087 CAC42766 AK299443 BAH13034 AL691746 BC039103 BC109096 BC109097 AAI09098 CR739116 DA561361 HG508011 XM_005256233 XP_005256290 XM_005256234 XP_005256291 XM_005256235 XP_005256292 XM_006721334 XP_006721397 XM_011523448 XP_011521750 XR_933482 NM_001308301 NP_001295230 NM_182493 NP_872299 |
Function | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Restricted to heart. {ECO:0000269|PubMed:17885681}. |
Top Pathways | Focal adhesion, Calcium signaling pathway, Vascular smooth muscle contraction, Gastric acid secretion, Oxytocin signaling pathway |
MYLK3 CRISPR/Cas9 KO Plasmid (h) - sc-413915 from Santa Cruz Biotechnology
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MYLK3 HDR Plasmid (h) - sc-413915-HDR from Santa Cruz Biotechnology
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MYLK3 Double Nickase Plasmid (h) - sc-413915-NIC from Santa Cruz Biotechnology
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MYLK3 Double Nickase Plasmid (h2) - sc-413915-NIC-2 from Santa Cruz Biotechnology
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MYLK3 CRISPR Activation Plasmid (h) - sc-413915-ACT from Santa Cruz Biotechnology
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MYLK3 CRISPR Activation Plasmid (h2) - sc-413915-ACT-2 from Santa Cruz Biotechnology
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MYLK3 Lentiviral Activation Particles (h) - sc-413915-LAC from Santa Cruz Biotechnology
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MYLK3 Lentiviral Activation Particles (h2) - sc-413915-LAC-2 from Santa Cruz Biotechnology
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MYLK3 siRNA (h) - sc-93234 from Santa Cruz Biotechnology
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MYLK3 shRNA Plasmid (h) - sc-93234-SH from Santa Cruz Biotechnology
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MYLK3 shRNA (h) Lentiviral Particles - sc-93234-V from Santa Cruz Biotechnology
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MYLK3 RNAi - H00091807-R02 from Novus Biologicals
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MISSION® esiRNA - EHU056851 from Sigma-Aldrich
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MISSION® siRNA - SIHK1359 from Sigma-Aldrich
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MISSION® siRNA - SIHK1357 from Sigma-Aldrich
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MISSION® siRNA - SIHK1358 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14841 from Sigma-Aldrich
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MYLK3 siRNA (Human) - CRJ4082 from Cohesion Biosciences
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shRNA set against Human MYLK3 (NM_182493.2) - SHH348024 from Creative biogene
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shRNA set against Human MLCK(NM_182493.2) - SHH191639 from Creative biogene
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Human MYLK3 siRNA - orb274583 from Biorbyt
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MYLK3 shRNA Plasmid (Human) - CHJ4082 from Cohesion Biosciences
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MYLK3 miRNA 3'UTR clone - MiUTR1H-06319 from Creative biogene
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