KCNQ1

Gene Symbol	KCNQ1
Entrez Gene	3784
Alt Symbol	ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated KQT-like subfamily Q, member 1
Other Description	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1|kidney and cardiac voltage dependend K+ channel|potassium voltage-gated channel subfamily KQT member 1|potassium voltage-gated channel, KQT-like subfamily, member 1|slow delayed rectifier channel subunit|voltage-gated potassium channel subunit Kv7.1
Swissprots	O00347 Q9UMN8 Q92960 Q7Z6G9 Q14D14 Q9UMN9 O60607 O94787 P51787
Accessions	BAA34738 BAA34739 CAB44649 CAB44650 EAX02517 EAX02518 EAX02519 EAX02520 EAX02521 P51787 AF000571 AAC51776 AF003743 AAC00066 AF051426 AAC05705 AI439544 AI473902 AJ006344 AK129678 AK290618 BAF83307 AY114213 AAM94040 BC017074 AAH17074 BC111847 AAI11848 BC113545 AAI13546 EF010934 ABJ98773 EF010935 ABJ98774 HQ258460 ADR83214 U86146 AAB53974 U89364 AAC51781 NM_000218 NP_000209 NM_181798 NP_861463 NM_181797
Function	Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18165683}; Multi-pass membrane protein {ECO:0000269|PubMed:18165683}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18165683}; Multi- pass membrane protein {ECO:0000269|PubMed:18165683}.
Tissue Specificity	Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.
Top Pathways	Vibrio cholerae infection, Protein digestion and absorption, Gastric acid secretion, Pancreatic secretion, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KCNQ1 (E-7) - sc-365764 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

KCNQ1 (C-20) - sc-10646 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

KCNQ1 (G-8) - sc-365186 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

KCNQ1 (H-130) - sc-20816 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

KCNQ1 (K-17) - sc-10645 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-KCNQ1 antibody - ab135737 from Abcam Prices $378.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-KCNQ1 antibody - ab192425 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KCNQ1 antibody - ab106812 from Abcam Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-KCNQ1 antibody [5E12] - ab124456 from Abcam Host Mouse Clonality Monoclonal Clone 5E12

Anti-KCNQ1 antibody [S37A-10] - ab84819 from Abcam Prices $387.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 antibody [S37A-10] (FITC) - ab183411 from Abcam Prices $372.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 antibody - N-terminal - ab170737 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, Atto 680) - LS-C230676 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, Atto 700) - LS-C230677 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa663-676) - LS-C112724 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, AP) - LS-C230678 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, APC) - LS-C230679 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, FITC) - LS-C230681 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, Biotin) - LS-C230680 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody - LS-C193091 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, PE, Atto 594) - LS-C230683 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, PerCP) - LS-C230684 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa4-33) - LS-C165445 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, RPE) - LS-C230685 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

Anti-KCNQ1 / KVLQT1 Antibody (aa2-101, clone S37A-10, Atto 594) - LS-C230688 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S37A-10

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