KCNQ1

Gene Symbol	KCNQ1
Entrez Gene	3784
Alt Symbol	ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated KQT-like subfamily Q, member 1
Other Description	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1|kidney and cardiac voltage dependend K+ channel|potassium voltage-gated channel subfamily KQT member 1|potassium voltage-gated channel, KQT-like subfamily, member 1|slow delayed rectifier channel subunit|voltage-gated potassium channel subunit Kv7.1
Swissprots	O00347 Q9UMN8 Q92960 Q7Z6G9 Q14D14 Q9UMN9 O60607 O94787 P51787
Accessions	BAA34738 BAA34739 CAB44649 CAB44650 EAX02517 EAX02518 EAX02519 EAX02520 EAX02521 P51787 AF000571 AAC51776 AF003743 AAC00066 AF051426 AAC05705 AI439544 AI473902 AJ006344 AK129678 AK290618 BAF83307 AY114213 AAM94040 BC017074 AAH17074 BC111847 AAI11848 BC113545 AAI13546 EF010934 ABJ98773 EF010935 ABJ98774 HQ258460 ADR83214 U86146 AAB53974 U89364 AAC51781 NM_000218 NP_000209 NM_181798 NP_861463 NM_181797
Function	Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18165683}; Multi-pass membrane protein {ECO:0000269|PubMed:18165683}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18165683}; Multi- pass membrane protein {ECO:0000269|PubMed:18165683}.
Tissue Specificity	Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.
Top Pathways	Vibrio cholerae infection, Protein digestion and absorption, Gastric acid secretion, Pancreatic secretion, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KCNQ1 / KVLQT1 Antibody Blocking Peptide - LS-E1442 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNQ1 / KVLQT1 Antibody Blocking Peptide - LS-E12441 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNQ1 / KVLQT1 Antibody Blocking Peptide - LS-E9866 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNQ1 / KVLQT1 Antibody Blocking Peptide - LS-E27011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNQ1-Antibody-N-term-Blocking-peptide - BP12143a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KCNQ1-Antibody-Center-Blocking-Peptide - BP8944c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KCNQ1 blocking peptide - GTX88458-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

KCNQ1 Blocking Peptide - 33R-8193 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNQ1 Blocking Peptide - 33R-4211 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Kv7.1 Blocking Peptide - abx062846 from Abbexa Category Peptide Species Human, Mouse, Rat

KCNQ1 Peptide - AC21-1836-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

KCNQ1 Peptide - 42-762P from ProSci Category Peptide Species Human

KCNQ1 fusion protein - ag17951 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

KCNQ1 fusion protein - Ag18251 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Kv7.1 Blocking Peptide - CBP1652 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1), Recombinant Protein - MBS1261467 from MyBioSource Category Protein Prices $2,430.00, $2,890.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1), Recombinant Protein - MBS962303 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

KCNQ1, Peptide - MBS425408 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Kv7.1, Peptide - MBS658104 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg Species Human

Kv7.1 Recombinant Protein Antigen - NBP2-31876PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KCNQ1 Peptide, Human - M34GP07999H from Creative Peptides Category Peptide Source Synthetic. Species Human

KCNQ1 peptide - orb217515 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1), Recombinant Protein - MBS7017772 from MyBioSource Category Protein Prices $1,465.00, $2,450.00, $3,655.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1), Recombinant Protein - MBS7017776 from MyBioSource Category Protein Prices $1,450.00, $2,435.00, $3,640.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression

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