KCNQ1

Gene Symbol KCNQ1
Entrez Gene 3784
Alt Symbol ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS
Species Human
Gene Type protein-coding
Description potassium channel, voltage gated KQT-like subfamily Q, member 1
Other Description IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1|kidney and cardiac voltage dependend K+ channel|potassium voltage-gated channel subfamily KQT member 1|potassium voltage-gated channel, KQT-like subfamily, member 1|slow delayed rectifier channel subunit|voltage-gated potassium channel subunit Kv7.1
Swissprots O00347 Q9UMN8 Q92960 Q7Z6G9 Q14D14 Q9UMN9 O60607 O94787 P51787
Accessions BAA34738 BAA34739 CAB44649 CAB44650 EAX02517 EAX02518 EAX02519 EAX02520 EAX02521 P51787 AF000571 AAC51776 AF003743 AAC00066 AF051426 AAC05705 AI439544 AI473902 AJ006344 AK129678 AK290618 BAF83307 AY114213 AAM94040 BC017074 AAH17074 BC111847 AAI11848 BC113545 AAI13546 EF010934 ABJ98773 EF010935 ABJ98774 HQ258460 ADR83214 U86146 AAB53974 U89364 AAC51781 NM_000218 NP_000209 NM_181798 NP_861463 NM_181797
Function Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Subcellular Location Cell membrane {ECO:0000269|PubMed:18165683}; Multi-pass membrane protein {ECO:0000269|PubMed:18165683}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18165683}; Multi- pass membrane protein {ECO:0000269|PubMed:18165683}.
Tissue Specificity Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.
Top Pathways Vibrio cholerae infection, Protein digestion and absorption, Gastric acid secretion, Pancreatic secretion, Adrenergic signaling in cardiomyocytes

KCNQ1 CRISPR/Cas9 KO Plasmid (h) - sc-400933 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 HDR Plasmid (h) - sc-400933-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 Double Nickase Plasmid (h) - sc-400933-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 Double Nickase Plasmid (h2) - sc-400933-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 CRISPR Activation Plasmid (h) - sc-400933-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 CRISPR Activation Plasmid (h2) - sc-400933-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 Lentiviral Activation Particles (h) - sc-400933-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 Lentiviral Activation Particles (h2) - sc-400933-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNQ1 siRNA (h) - sc-35745 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNQ1 shRNA Plasmid (h) - sc-35745-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNQ1 shRNA (h) Lentiviral Particles - sc-35745-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Kv7.1 RNAi - H00003784-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Kv7.1 RNAi - H00003784-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Kv7.1 RNAi - H00003784-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU071311 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU026051 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10985 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10985 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08207 from Sigma-Aldrich

Category miRNA

KCNQ1 siRNA (Human) - CRH2558 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Kcnq1 (NM_000218.2) - SHH323635 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KCNQ1(NM_000218.2) - SHL191082 from Creative biogene

Category siRNA
Species Reactivities Human

Human KCNQ1 siRNA - orb263060 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KCNQ1 shRNA Plasmid (Human) - CHH2558 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KCNQ1 miRNA 3'UTR clone - MiUTR1H-05163 from Creative biogene

Species Reactivities Human
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