KCNQ1

Gene Symbol KCNQ1
Entrez Gene 3784
Alt Symbol ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS
Species Human
Gene Type protein-coding
Description potassium channel, voltage gated KQT-like subfamily Q, member 1
Other Description IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1|kidney and cardiac voltage dependend K+ channel|potassium voltage-gated channel subfamily KQT member 1|potassium voltage-gated channel, KQT-like subfamily, member 1|slow delayed rectifier channel subunit|voltage-gated potassium channel subunit Kv7.1
Swissprots O00347 Q9UMN8 Q92960 Q7Z6G9 Q14D14 Q9UMN9 O60607 O94787 P51787
Accessions BAA34738 BAA34739 CAB44649 CAB44650 EAX02517 EAX02518 EAX02519 EAX02520 EAX02521 P51787 AF000571 AAC51776 AF003743 AAC00066 AF051426 AAC05705 AI439544 AI473902 AJ006344 AK129678 AK290618 BAF83307 AY114213 AAM94040 BC017074 AAH17074 BC111847 AAI11848 BC113545 AAI13546 EF010934 ABJ98773 EF010935 ABJ98774 HQ258460 ADR83214 U86146 AAB53974 U89364 AAC51781 NM_000218 NP_000209 NM_181798 NP_861463 NM_181797
Function Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
Subcellular Location Cell membrane {ECO:0000269|PubMed:18165683}; Multi-pass membrane protein {ECO:0000269|PubMed:18165683}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18165683}; Multi- pass membrane protein {ECO:0000269|PubMed:18165683}.
Tissue Specificity Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.
Top Pathways Vibrio cholerae infection, Protein digestion and absorption, Gastric acid secretion, Pancreatic secretion, Adrenergic signaling in cardiomyocytes

KCNQ1 overexpression lysate - LY405589 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

KCNQ1 293 Cell Lysate - 403656 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

Kv7.1 Overexpression Lysate (Native) - NBP2-09069 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: KCNQ1 Overexpression Lysate (Adult Normal) [NBP2-09069] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNQ1.

Kv7.1 Overexpression Lysate (Native) - NBP2-09045 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: KCNQ1 Overexpression Lysate (Adult Normal) [NBP2-09045] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNQ1.

KCNQ1 (h): 293T Lysate - sc-128911 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

KCNQ1 Over-expression Lysate Product - GWB-557B02 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Kv7.1 Overexpression Lysate (Native) - NBP2-04880 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: Kv7.1 Overexpression Lysate (Native) [NBP2-04880] - Kv7.1 Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNQ1.

Panoply™ Human KCNQ1 Knockdown Stable Cell Line - CSC-DC007999 from Creative biogene

Category Cell Line
Species Human
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