| Gene Symbol |
MTPAP
|
| Entrez Gene |
55149
|
| Alt Symbol |
PAPD1, SPAX4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial poly(A) polymerase
|
| Other Description |
PAP-associated domain-containing protein 1|TUTase 1|poly(A) RNA polymerase, mitochondrial|polynucleotide adenylyltransferase|terminal uridylyltransferase 1
|
| Swissprots |
D3DRX0 Q6P7E5 Q659E3 Q9NVV4 Q9HA74
|
| Accessions |
EAW86014 EAW86015 Q9NVV4 AB194709 BAD98252 AK001348 BAA91641 AK022188 BAB13981 AK125211 AY364242 AAQ76801 BC061703 AAH61703 DA086747 NM_018109 NP_060579
|
| Function |
Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. {ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20970105, ECO:0000269|PubMed:21292163}.
|
| Subcellular Location |
Cytoplasm. Mitochondrion.
|
| Tissue Specificity |
Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle. {ECO:0000269|PubMed:15547249}.
|