TERF2

Gene Symbol	TERF2
Entrez Gene	7014
Alt Symbol	TRBF2, TRF2
Species	Human
Gene Type	protein-coding
Description	telomeric repeat binding factor 2
Other Description	TTAGGG repeat-binding factor 2|telomeric DNA-binding protein|telomeric repeat binding protein 2|telomeric repeat-binding factor 2
Swissprots	Q15554
Accessions	EAW83273 EAW83274 Q15554 AF002999 AAB81135 BC024890 AAH24890 BX090758 CB216181 HY046320 U95970 AAD00821 X93512 CAA63769 XM_005256121 XP_005256178 XM_005256122 XP_005256179 XM_005256123 XP_005256180 XM_005256124 XP_005256181 XM_011523308 XP_011521610 NM_005652 NP_005643
Function	Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation a
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00625, ECO:0000269|PubMed:20655466}. Chromosome, telomere {ECO:0000269|PubMed:20655466}. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Tissue Specificity	Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRF2 full length protein - ab152737 from Abcam Category Protein Source Wheat germ Species Human

Human TRF2 peptide - ab13765 from Abcam Category Peptide

TERF2 / TRF2 Antibody Blocking Peptide - LS-E2763 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TERF2 / TRF2 Antibody Blocking Peptide - LS-E10533 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRF-2 Protein - H00007014-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

TERF2-Antibody-Center-Blocking-peptide - BP13860c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAP1 blocking peptide - GTX88131-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

TERF2 Protein Lysate (APL10171) - APL10171 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

TERF2 Protein Lysate (APL10172) - APL10172 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

TERF2 Blocking Peptide - 33R-9346 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRF2 Blocking Peptide - abx064215 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

TERF2 - H00007014-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

TERF2 control peptide - AP10357CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

TERF2 control peptide - AP10358CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

TERF2 control peptide - AP10359CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

TERF2 Peptide - 7727P from ProSci Category Peptide Species Human

TERF2 fusion protein - ag16798 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Telomeric Repeat Binding Factor 2 (TERF2) - RPF384Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

TRF2 Blocking Peptide - CBP3021 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Recombinant Telomeric Repeat Binding Factor 2 (TERF2) - RPF384Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Telomeric repeat-binding factor 2(TERF2) - CSB-YP620883HU CSB-EP620883HU CSB-BP620883HU CSB-MP620883HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRF2 (49-300) - sc-4545 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

Telomeric Repeat Binding Factor 2 Protein (Recombinant) - abx167007 from Abbexa Category Protein Source Human Species Human

TERF2 - TP323601 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Telomeric Repeat Binding Factor 2, Recombinant Protein - MBS2031120 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

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