TERF2

Gene Symbol TERF2
Entrez Gene 7014
Alt Symbol TRBF2, TRF2
Species Human
Gene Type protein-coding
Description telomeric repeat binding factor 2
Other Description TTAGGG repeat-binding factor 2|telomeric DNA-binding protein|telomeric repeat binding protein 2|telomeric repeat-binding factor 2
Swissprots Q15554
Accessions EAW83273 EAW83274 Q15554 AF002999 AAB81135 BC024890 AAH24890 BX090758 CB216181 HY046320 U95970 AAD00821 X93512 CAA63769 XM_005256121 XP_005256178 XM_005256122 XP_005256179 XM_005256123 XP_005256180 XM_005256124 XP_005256181 XM_011523308 XP_011521610 NM_005652 NP_005643
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation a
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00625, ECO:0000269|PubMed:20655466}. Chromosome, telomere {ECO:0000269|PubMed:20655466}. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Tissue Specificity Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.

Trf2 Antibody - 2645 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS-7, HT29 and RD-ES cells, using Trf2 Antibody.

TRF2 (D1Y5D) Rabbit mAb - 13136 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1Y5D
Western blot analysis of extracts from various cell lines using TRF2 (D1Y5D) Rabbit mAb.

TRF2 (B-5) - sc-271710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRF2 (B-5): sc-271710. Western blot analysis of TRF2 expression in K-562 nuclear extract.

TRF2 (9F10) - sc-47693 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRF2 (9F10): sc-47693. Western blot analysis of TRF2 expression in HeLa (A), Jurkat (B) and K-562 (C) whole cell lysates.

TRF2 (E-20) - sc-32106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRF2 (E-20): sc-32106. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

TRF2 (H-300) - sc-9143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRF2 (H-300): sc-9143. Western blot analysis of TRF2 expression in NAMALWA whole cell lysate.

TRF2 (R-18) - sc-32104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRF2 (N-20) - sc-8528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRF2 (N-20): sc-8528. Western blot analysis of TRF2 expression in Jurkat (A) and K-562 (B) nuclear extracts and NAMALWA whole cell lysate (C).

TRF2 (36) - sc-136110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
TRF2 (36): sc-136110. Western blot analysis of TRF2 expression in Jurkat whole cell lysate.

TRF2 (4A794) - sc-52968 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TRF2 (4A794): sc-52968. Western blot analysis of TRF2 expression in K-562 (A) and Jurkat (B) nuclear extracts and K-562 (C) and NAMALWA (D) whole cell lysates.

Anti-TRF2 antibody - ab4182 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRF2 antibody (ab4182) at 1 µg/mlLane 1 : HeLa nuclear extractLane 2 : HeLa whole cell lysateLane 3 : HeLa nuclear lysate with Human TRF2 peptide (ab13765) at 1 µg/mlLane 4 : HeLa whole cell lysate with Human TRF2 peptide (ab13765) at 1 µg/mlLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab6721) at 1/5000 dilution

Anti-TRF2 antibody - ab69851 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRF2 antibody (ab69851) at 5 µg/ml + Transfected 293T cell lysates at 10 µgSecondaryanti-Rabbit IgG HRP at 1/50000 dilution

Anti-TRF2 antibody - ab111118 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111118, at 3.75µg/ml, staining TRF2 in formalin-fixed, paraffin-embedded Human Testis tissue by Immunohistochemistry.

Anti-TRF2 antibody - ab13589 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunoprecipitation (IP)/ Western Blot (WB) Analysis of TRF2 in human cell lysates. Lane 1. IP with TRF2 antibody (mouse ant-TRF2). Lane 2. IP with control mouse IgG. Lane 3. IP with TRF2 antibody (goat anti-TRF2). Lane 4. IP with pre-immune goat Ig. Lanes 1-4. WB with TRF2 antibody. TRF2 is detected as an ~ 66 kD protein.

Anti-TRF2 antibody [3H6B4] - C-terminal - ab181747 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H6B4
Immunohistochemical analysis of paraffin embedded Human ovarian cancer tissue labeling TRF2 with ab181747 at 1/200.

Anti-TRF2 antibody [4A794] - ChIP Grade - ab13579 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A794
ab13579 staining TRF2 in bladder carcinoma cells using Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Antigeen retrieval carried out by heat treatment in Citrate buffer pH6.0. Primary antibody diluted to 4μg/ml.

Anti-TRF2 antibody [EPR3517(2)] - ab108997 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3517(2)
All lanes : Anti-TRF2 antibody [EPR3517(2)] (ab108997) at 1/1000 dilutionLane 1 : HT29 cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-TRF2 antibody [EPR3517(2)] (Alexa Fluor® 488) - ab198595 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3517(2)
Overlay histogram showing HeLa cells stained with ab198595 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab198595, 1/500 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 488 (ab199091) used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% formaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-TRF2 antibody [EPR3517(2)] (Alexa Fluor® 647) - ab198597 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3517(2)
Overlay histogram showing HeLa cells stained with ab198597 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab198597, 1/500 dilution) for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) Alexa Fluor® 647 (ab199093) used at the same concentration and conditions as the primary antibody. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a solid-state 25mW red diode laser (635 nm) and 675/30 bandpass filter.

Anti-TRF2 antibody [EPR3518(2)] - ab108932 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3518(2)
All lanes : Anti-TRF2 antibody [EPR3518(2)] (ab108932) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : NAMALWA cell lysateLysates/proteins at 10 µg per lane.

Anti-TRF2 antibody [mta18 9f10/1] - ab14402 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mta18 9f10/1

Anti-TRF2 antibody - N-terminal - ab191704 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRF2 antibody - N-terminal (ab191704) at 1 µg/ml + 293 cell lysate at 15 µg

Anti-TERF2 / TRF2 Antibody - LS-C92685 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-TERF2 / TRF2 Antibody - LS-C92688 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TERF2 / TRF2 Antibody - LS-C92689 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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