TERF2

Gene Symbol TERF2
Entrez Gene 7014
Alt Symbol TRBF2, TRF2
Species Human
Gene Type protein-coding
Description telomeric repeat binding factor 2
Other Description TTAGGG repeat-binding factor 2|telomeric DNA-binding protein|telomeric repeat binding protein 2|telomeric repeat-binding factor 2
Swissprots Q15554
Accessions EAW83273 EAW83274 Q15554 AF002999 AAB81135 BC024890 AAH24890 BX090758 CB216181 HY046320 U95970 AAD00821 X93512 CAA63769 XM_005256121 XP_005256178 XM_005256122 XP_005256179 XM_005256123 XP_005256180 XM_005256124 XP_005256181 XM_011523308 XP_011521610 NM_005652 NP_005643
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation a
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00625, ECO:0000269|PubMed:20655466}. Chromosome, telomere {ECO:0000269|PubMed:20655466}. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Tissue Specificity Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.

TRF2 CRISPR/Cas9 KO Plasmid (h) - sc-401289 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 HDR Plasmid (h) - sc-401289-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 Double Nickase Plasmid (h) - sc-401289-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 Double Nickase Plasmid (h2) - sc-401289-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 CRISPR Activation Plasmid (h) - sc-401289-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 CRISPR Activation Plasmid (h2) - sc-401289-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 Lentiviral Activation Particles (h) - sc-401289-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 Lentiviral Activation Particles (h2) - sc-401289-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRF2 siRNA (h) - sc-38505 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRF2 shRNA Plasmid (h) - sc-38505-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRF2 shRNA (h) Lentiviral Particles - sc-38505-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRF-2 RNAi - H00007014-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU042991 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21219 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21219 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TERF2 siRNA (Human) - CRH4790 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TERF2 - MBS8230868 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TERF2 shRNA Plasmid (Human) - CHH4790 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TERF2 miRNA 3'UTR clone - MiUTR3H-04610 from Creative biogene

Species Reactivities Human
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