| Gene Symbol |
MAFB
|
| Entrez Gene |
9935
|
| Alt Symbol |
KRML, MCTO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
|
| Other Description |
Kreisler maf-related leucine zipper homolog|MAFB/Kreisler basic region/leucine zipper transcription factor|transcription factor MafB
|
| Swissprots |
Q9Y5Q3 B3KNE1 Q9H1F1
|
| Accessions |
EAW76000 Q9Y5Q3 AF086178 AF134157 AAD30106 AK027324 BAG51303 BC028098 AAH28098 BC036689 AAH36689 BQ271704 DA719830 NM_005461 NP_005452
|
| Function |
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. {ECO:0000250, ECO:0000269|PubMed:19143053}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10444328}.
|