MAFB

Gene Symbol MAFB
Entrez Gene 9935
Alt Symbol KRML, MCTO
Species Human
Gene Type protein-coding
Description v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
Other Description Kreisler maf-related leucine zipper homolog|MAFB/Kreisler basic region/leucine zipper transcription factor|transcription factor MafB
Swissprots Q9Y5Q3 B3KNE1 Q9H1F1
Accessions EAW76000 Q9Y5Q3 AF086178 AF134157 AAD30106 AK027324 BAG51303 BC028098 AAH28098 BC036689 AAH36689 BQ271704 DA719830 NM_005461 NP_005452
Function Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. {ECO:0000250, ECO:0000269|PubMed:19143053}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10444328}.

MafB CRISPR/Cas9 KO Plasmid (h) - sc-400554 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB HDR Plasmid (h) - sc-400554-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB Double Nickase Plasmid (h) - sc-400554-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB Double Nickase Plasmid (h2) - sc-400554-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB CRISPR Activation Plasmid (h) - sc-400554-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB CRISPR Activation Plasmid (h2) - sc-400554-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB Lentiviral Activation Particles (h) - sc-400554-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB Lentiviral Activation Particles (h2) - sc-400554-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafB siRNA (h) - sc-35839 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MafB shRNA Plasmid (h) - sc-35839-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MafB shRNA (h) Lentiviral Particles - sc-35839-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MafB RNAi - H00009935-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN12903 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MAFB siRNA (Human) - CRH6677 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MAFB (NM_005461.3) - SHH336639 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MAFB(NM_005461.3) - SHH170273 from Creative biogene

Category siRNA
Species Reactivities Human

MAFB shRNA Plasmid (Human) - CHH6677 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAFB miRNA 3'UTR clone - MiUTR1H-06001 from Creative biogene

Species Reactivities Human
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