| Gene Symbol |
Hmgcl
|
| Entrez Gene |
15356
|
| Alt Symbol |
AW476067, HL
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
3-hydroxy-3-methylglutaryl-Coenzyme A lyase
|
| Other Description |
3-hydroxy-3-methylglutarate-CoA lyase|HMG-CoA lyase|hydroxymethylglutaryl-CoA lyase, mitochondrial
|
| Swissprots |
Q8QZS6 P38060
|
| Accessions |
AAB03107 EDL29963 P38060 AK077842 AK132035 BAE20956 AK144768 BAE26056 AK145251 BAE26328 AK154033 BAE32329 AK182431 AK210917 AK217644 BB852743 BC025440 AAH25440 BX631310 S65036 AAB27965 XM_006538563 XP_006538626 XM_006538564 XP_006538627 NM_008254 NP_032280
|
| Function |
Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:7527399}. Peroxisome {ECO:0000269|PubMed:7527399}. Note=Unprocessed form is peroxisomal.
|
| Top Pathways |
Peroxisome, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism
|
