Gene Symbol | HMOX1 |
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Entrez Gene | 3162 |
Alt Symbol | HMOX1D, HO-1, HSP32, bK286B10 |
Species | Human |
Gene Type | protein-coding |
Description | heme oxygenase 1 |
Other Description | heat shock protein, 32-kD|heme oxygenase (decycling) 1 |
Swissprots | P09601 |
Accessions | AAR23262 CAA32886 EAW60059 P09601 AF051791 AK313120 BAG35941 BC001491 AAH01491 BP288767 BT019785 AAV38588 CA306357 CR456505 CAG30391 CR541945 CAG46743 CR541968 CAG46766 CU013103 CAK54534 CU013391 CAK54833 DQ892310 ABM83236 DQ895510 ABM86436 GU187011 ACZ72606 GU187012 ACZ72607 JF323038 ADZ76424 M23041 AAA50403 M23042 X06985 CAA30045 NM_002133 NP_002124 |
Function | Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. |
Subcellular Location | Microsome {ECO:0000269|PubMed:22419571}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22419571}; Peripheral membrane protein {ECO:0000269|PubMed:22419571}; Cytoplasmic side {ECO:0000269|PubMed:22419571}. |
Tissue Specificity | Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). {ECO:0000269|PubMed:20855888}. |
Top Pathways | Mineral absorption, MicroRNAs in cancer, Porphyrin and chlorophyll metabolism |
Human Heme Oxygenase 1 full length protein - ab113188 from Abcam
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Human Heme Oxygenase 1 full length protein - ab85243 from Abcam
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Human Heme Oxygenase 1 peptide - ab94374 from Abcam
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Human Heme Oxygenase 1 protein fragment - ab86919 from Abcam
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Rat Heme Oxygenase 1 full length protein - ab92366 from Abcam
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HMOX1 / HO-1 Antibody Blocking Peptide - LS-E861 from LifeSpan Bioscience
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HMOX1 / HO-1 Antibody Blocking Peptide - LS-E16564 from LifeSpan Bioscience
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HO-1/HMOX1/HSP32 Recombinant Protein - H00003162-P01 from Novus Biologicals
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HO-1/HMOX1/HSP32 Partial Recombinant Protein - H00003162-Q01 from Novus Biologicals
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HO-1/HMOX1/HSP32 Protein - NBC1-22928 from Novus Biologicals
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HMOX1-Antibody-Center-Blocking-peptide - BP11240c from Abgent, a WuXi AppTec company
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Recombinant Human HO-1/HMOX1, CF - 3776-HM-020 from R&D Systems
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Recombinant human Heme oxygenase 1 (OPCA00119) - OPCA00119 from Aviva Systems Biology
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HMOX1 Protein (OPPA02223) - OPPA02223 from Aviva Systems Biology
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Human HMOX1 protein - orb246361 from Biorbyt
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Human HSP32 protein - orb49433 from Biorbyt
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Human HMOX1 protein - orb90142 from Biorbyt
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Heme oxygenase 1 protein (His tag) - 80R-1099 from Fitzgerald
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HMOX1 Blocking Peptide - 33R-10739 from Fitzgerald
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Human HO1 Protein - abx067033 from Abbexa
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Heme oxygenase 1 / HMOX1 (1-266, His-tag) - AR50031PU-N from Acris Antibodies
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Heme oxygenase 1 / HMOX1 (1-266, His-tag) - AR50031PU-S from Acris Antibodies
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Heme oxygenase 1 / HMOX1 - H00003162-P01-10 from Acris Antibodies
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Heme oxygenase 1 / HMOX1 - H00003162-P01-25 from Acris Antibodies
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Heme oxygenase 1 / HMOX1 - H00003162-Q01-10 from Acris Antibodies
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