HMOX1

Gene Symbol HMOX1
Entrez Gene 3162
Alt Symbol HMOX1D, HO-1, HSP32, bK286B10
Species Human
Gene Type protein-coding
Description heme oxygenase 1
Other Description heat shock protein, 32-kD|heme oxygenase (decycling) 1
Swissprots P09601
Accessions AAR23262 CAA32886 EAW60059 P09601 AF051791 AK313120 BAG35941 BC001491 AAH01491 BP288767 BT019785 AAV38588 CA306357 CR456505 CAG30391 CR541945 CAG46743 CR541968 CAG46766 CU013103 CAK54534 CU013391 CAK54833 DQ892310 ABM83236 DQ895510 ABM86436 GU187011 ACZ72606 GU187012 ACZ72607 JF323038 ADZ76424 M23041 AAA50403 M23042 X06985 CAA30045 NM_002133 NP_002124
Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Subcellular Location Microsome {ECO:0000269|PubMed:22419571}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22419571}; Peripheral membrane protein {ECO:0000269|PubMed:22419571}; Cytoplasmic side {ECO:0000269|PubMed:22419571}.
Tissue Specificity Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). {ECO:0000269|PubMed:20855888}.
Top Pathways Mineral absorption, MicroRNAs in cancer, Porphyrin and chlorophyll metabolism

HO-1 (P249) Antibody - 5061 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or arsenite-treated, using HO-1 (P249) Antibody.

HO-1 (D60G11) Rabbit mAb - 5853 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D60G11
Western blot analysis of extracts from HeLa cells, untreated or Arsenic-treated, using HO-1 (D60G11) Rabbit mAb.

HO-1 (P109) Antibody - 5141 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa cells, untreated or arsenite-treated, using HO-1 (P109) Antibody.

Heme Oxygenase 1 (C-18) - sc-1796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Heme Oxygenase 1 (C-18): sc-1796. Western blot analysis of Heme Oxygenase 1 expression in non-transfected: sc-117752 (A) and mouse Heme Oxygenase 1 transfected: sc-120745 (B) 293T whole cell lysates.

Heme Oxygenase 1 (C-20) - sc-7695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Heme Oxygenase 1 (C-20): sc-7695. Western blot analysis of Heme Oxygenase 1 expression in mouse spleen extract.

Heme Oxygenase 1 (D-8) - sc-136961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Heme Oxygenase 1 (D-8): sc-136961. Western blot analysis of Heme Oxygenase 1 expression in HeLa whole cell lysate.

Heme Oxygenase 1 (F-4) - sc-390991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Heme Oxygenase 1 (F-4): sc-390991. Western blot analysis of Heme Oxygenase 1 expression in non-transfected: sc-117752 (A) and mouse Heme Oxygenase 1 transfected: sc-120745 (B) 293T whole cell lysates.

Heme Oxygenase 1 (H-105) - sc-10789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Heme Oxygenase 1 (H-105): sc-10789. Western blot analysis of Heme Oxygenase 1 expression in non-transfected: sc-117752 (A) and mouse Heme Oxygenase 1 transfected: sc-120745 (B) 293T whole cell lysates.

Heme Oxygenase 1 (M-19) - sc-1797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Heme Oxygenase 1 (M-19): sc-1797. Immunofluorescence staining of methanol-fixed NIH/3T3 + HS cells showing cytoplasmic localization.

Heme Oxygenase 1 (N-19) - sc-7696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Heme Oxygenase 1 (N-19): sc-7696. Western blot analysis of Heme Oxygenase 1 expression in rat spleen tissue extract.

Heme Oxygenase 1 (A-3) - sc-136960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Heme Oxygenase 1 (A-3): sc-136960. Western blot analysis of Heme Oxygenase 1 expression in HeLa whole cell lysate.

Heme Oxygenase 1 (23) - sc-136256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Heme Oxygenase 1 (23): sc-136256. Immunofluorescence staining of HeLa cells showing cytoplasmic localization.

Anti-Heme Oxygenase 1 antibody - ab85309 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistical detection of Anti-Heme Oxygenase 1 antibody (ab85309; 1/5000 for 2h @ 21°C) on human lung formalin/PFA-fixed paraffin-embedded sections. Antigen retrieval step:Heat mediated - Buffer/Enzyme Used: Citric acid.Blocking step: 1% BSA for 10 mins at 21°C. Secondary antibody biotin conjugated anti Rabbit IgG (1/200). NB: Positivity appears to be confined to macrophages- the primary antibody was omitted on the sequential section and was negative for macrophages ( to rule out lipofuscin).See Abreview

Anti-Heme Oxygenase 1 antibody - ab137749 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Heme Oxygenase 1 antibody (ab137749) at 1/1000 dilutionLane 1 : H1299 cell lysateLane 2 : HeLa cell lysateLysates/proteins at 30 µg per lane.

Anti-Heme Oxygenase 1 antibody - ab156926 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Heme Oxygenase 1 staining in human normal liver formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab156926, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Heme Oxygenase 1 antibody - ab82219 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Heme Oxygenase 1 antibody (ab82219) at 1/1000 dilutionLane 1 : Molecular weight markerLane 2 : Recombinant ProteinLane 3 : Human liver microsomesLane 4 : Mouse liver microsomesLane 5 : Rat liver microsomes

Anti-Heme Oxygenase 1 antibody - ab130994 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Heme Oxygenase 1 by Western Blot of Immunoprecipitates. HeLa whole cell lysate immunoprecipitated using ab130994 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-Heme Oxygenase 1 antibody [EP1391Y] - ab52947 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1391Y
Overlay histogram showing HEK293 cells stained with ab52947 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab52947, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HEK293 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Heme Oxygenase 1 antibody [EPR1390Y] - ab68477 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1390Y
ab68477 staining Heme Oxygenase 1 in mouse embryonic fibroblasts by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with formaldehyde, permeabilized with 0.2% Triton X-100 and blocked with 1.5% serum for 10 minutes at 25°C. Samples were incubated with primary antibody (1/100 in 1X HBSS + 0.02% Triton X-100 + 1.5% FBS) for 3 hours at 25°C. An Alexa Fluor® 594-conjugated goat anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody.See Abreview

Anti-Heme Oxygenase 1 antibody [GTS-1] - ab12220 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone GTS-1
Overlay histogram showing HEK293 cells stained with ab12220 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab12220, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in HEK293 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-HMOX1 / HO-1 Antibody (aa12-25) - LS-C11351 from LifeSpan Bioscience

Prices $550.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HMOX1 / HO-1 Antibody (aa12-25) - LS-C15674 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HMOX1 / HO-1 Antibody (N-Terminus) - LS-C15735 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HMOX1 / HO-1 Antibody (N-Terminus) - LS-C15736 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HMOX1 / HO-1 Antibody (N-Terminus) - LS-C15737 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
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