| Gene Symbol |
ZC3HC1
|
| Entrez Gene |
51530
|
| Alt Symbol |
HSPC216, NIPA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, C3HC-type containing 1
|
| Other Description |
hematopoietic stem/progenitor cell protein 216|nuclear interacting partner of anaplastic lymphoma kinase (ALK)|nuclear-interacting partner of ALK
|
| Swissprots |
Q9HA34 Q8N330 Q86WB0 Q9NVX4 A6NH66 Q75MF4 Q96F75 Q75MF3 Q9P0R0
|
| Accessions |
AAS07546 AAS07547 CAE89297 EAL24097 EAW83738 EAW83739 EAW83740 EAW83741 EAW83742 EAW83743 Q86WB0 AF151050 AAF36136 AJ537494 CAD61161 AK001317 BAA91619 AK022373 BAB14024 AM393415 CAL38293 BC000190 AAH00190 BC011551 AAH11551 BC028917 AAH28917 BF745935 BI830062 BM013594 BX490781 DA066102 XM_005250403 XP_005250460 XM_011516288 XP_011514590 XM_011516289 XP_011514591 XM_011516290 XP_011514592 NM_001282190 NP_001269119 NM_001282191 NP_001269120 NM_016478 NP_057562
|
| Function |
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. {ECO:0000269|PubMed:16009132}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12748172}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. {ECO:0000269|PubMed:12748172}.
|