ZC3HC1

Gene Symbol	ZC3HC1
Entrez Gene	51530
Alt Symbol	HSPC216, NIPA
Species	Human
Gene Type	protein-coding
Description	zinc finger, C3HC-type containing 1
Other Description	hematopoietic stem/progenitor cell protein 216|nuclear interacting partner of anaplastic lymphoma kinase (ALK)|nuclear-interacting partner of ALK
Swissprots	Q9HA34 Q8N330 Q86WB0 Q9NVX4 A6NH66 Q75MF4 Q96F75 Q75MF3 Q9P0R0
Accessions	AAS07546 AAS07547 CAE89297 EAL24097 EAW83738 EAW83739 EAW83740 EAW83741 EAW83742 EAW83743 Q86WB0 AF151050 AAF36136 AJ537494 CAD61161 AK001317 BAA91619 AK022373 BAB14024 AM393415 CAL38293 BC000190 AAH00190 BC011551 AAH11551 BC028917 AAH28917 BF745935 BI830062 BM013594 BX490781 DA066102 XM_005250403 XP_005250460 XM_011516288 XP_011514590 XM_011516289 XP_011514591 XM_011516290 XP_011514592 NM_001282190 NP_001269119 NM_001282191 NP_001269120 NM_016478 NP_057562
Function	Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. {ECO:0000269|PubMed:16009132}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12748172}.
Tissue Specificity	Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. {ECO:0000269|PubMed:12748172}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human NIPA Protein - H00051530-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human NIPA Protein - H00051530-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ZC3HC1 - H00051530-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZC3HC1 - H00051530-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZC3HC1 - H00051530-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ZC3HC1 - H00051530-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZC3HC1 - H00051530-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZC3HC1 fusion protein - Ag3744 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ZC3HC1, GST-tagged - ZC3HC1-3788H from Creative Biomart Category Protein Source E.coli Species Human

NIPA (S350) Peptide - BS1847P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Nuclear-interacting partner of ALK(ZC3HC1) - CSB-YP801246HU CSB-EP801246HU CSB-BP801246HU CSB-MP801246HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NIPA (pS354) Blocking Peptide - abx162078 from Abbexa Category Peptide Species Human, Monkey

NIPA Blocking Peptide - abx162079 from Abbexa Category Peptide Species Human, Mouse, Monkey

ZC3HC1 Peptide, Human - M34GP17726H from Creative Peptides Category Peptide Source Synthetic. Species Human

NIPA (pS354) Blocking Peptide - CBP4867 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Monkey

NIPA Blocking Peptide - CBP4868 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Monkey

NIPA Recombinant Protein Antigen - NBP1-82565PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NIPA Recombinant Protein Antigen - NBP1-82564PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NIPA peptide - orb316012 from Biorbyt Category Peptide Prices $247.00, $510.00 Sizes 1 mg, 5 mg

Nuclear-interacting partner of ALK (ZC3HC1), Recombinant Protein - MBS1319379 from MyBioSource Category Protein Prices $1,290.00, $1,290.00, $1,510.00, $1,510.00, $2,115.00, $2,115.00, $2,580.00, $2,580.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

NIPA (Phospho-S354) peptide - orb316011 from Biorbyt Category Peptide

Search more