ZC3HC1

Gene Symbol ZC3HC1
Entrez Gene 51530
Alt Symbol HSPC216, NIPA
Species Human
Gene Type protein-coding
Description zinc finger, C3HC-type containing 1
Other Description hematopoietic stem/progenitor cell protein 216|nuclear interacting partner of anaplastic lymphoma kinase (ALK)|nuclear-interacting partner of ALK
Swissprots Q9HA34 Q8N330 Q86WB0 Q9NVX4 A6NH66 Q75MF4 Q96F75 Q75MF3 Q9P0R0
Accessions AAS07546 AAS07547 CAE89297 EAL24097 EAW83738 EAW83739 EAW83740 EAW83741 EAW83742 EAW83743 Q86WB0 AF151050 AAF36136 AJ537494 CAD61161 AK001317 BAA91619 AK022373 BAB14024 AM393415 CAL38293 BC000190 AAH00190 BC011551 AAH11551 BC028917 AAH28917 BF745935 BI830062 BM013594 BX490781 DA066102 XM_005250403 XP_005250460 XM_011516288 XP_011514590 XM_011516289 XP_011514591 XM_011516290 XP_011514592 NM_001282190 NP_001269119 NM_001282191 NP_001269120 NM_016478 NP_057562
Function Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. {ECO:0000269|PubMed:16009132}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12748172}.
Tissue Specificity Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes. {ECO:0000269|PubMed:12748172}.

NIPA CRISPR/Cas9 KO Plasmid (h) - sc-410586 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA HDR Plasmid (h) - sc-410586-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA Double Nickase Plasmid (h) - sc-410586-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA Double Nickase Plasmid (h2) - sc-410586-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA CRISPR Activation Plasmid (h) - sc-410586-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA CRISPR Activation Plasmid (h2) - sc-410586-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA Lentiviral Activation Particles (h) - sc-410586-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA Lentiviral Activation Particles (h2) - sc-410586-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NIPA siRNA (h) - sc-61197 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NIPA shRNA Plasmid (h) - sc-61197-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NIPA shRNA (h) Lentiviral Particles - sc-61197-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU133641 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN23110 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23110 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03771 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03771

ZC3HC1 siRNA (Human) - CRH9814 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZC3HC1 - MBS8230696 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ZC3HC1 (NM_016478.3) - SHH449552 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ZC3HC1(NM_016478.3) - SHL143460 from Creative biogene

Category siRNA
Species Reactivities Human

Human ZC3HC1 siRNA - orb270316 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZC3HC1 shRNA Plasmid (Human) - CHH9814 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ZC3HC1 miRNA 3'UTR clone - MiUTR1H-11400 from Creative biogene

Species Reactivities Human
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