| Gene Symbol |
FAM162A
|
| Entrez Gene |
26355
|
| Alt Symbol |
C3orf28, E2IG5, HGTD-P
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
family with sequence similarity 162, member A
|
| Other Description |
E2-induced gene 5 protein|HIF-1 alpha-responsive proapoptotic molecule|growth and transformation-dependent protein|protein FAM162A
|
| Swissprots |
Q9UJX8 Q9NRN6 Q96A26
|
| Accessions |
EAW79486 Q96A26 AF107495 AAG39275 AF191020 AAF09484 AF201944 AAF86880 AF250321 AAG44569 AK026030 AK125835 AK293994 BAG57358 BC010896 AAH10896 BC015060 AAH15060 BI460077 NM_014367 NP_055182
|
| Function |
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. {ECO:0000269|PubMed:15082785}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:16698020}.
|